摘要
基因表达图谱将乳腺癌分为4种亚型:基底亚型、HER2阳性亚型、luminal-A亚型和luminal-B亚型。尽管都表达雌激素受体,也都接受了内分泌治疗,但luminal-B亚型较luminal-A亚型的复发风险明显增加。Luminal-B亚型的典型特点是高表达增殖相关基因,一些可能改善其预后的相关信号通路靶点也在研究中。本文回顾了luminal-B亚型乳腺癌的基因表达特点、病理和临床特征以及目前正在研发的治疗靶点。
Breast cancer can be classified into four intrinsic subtypes by gene expression profiling： basal-like, HER2- positive, luminal-A and luminal-B. In spite of expressing estrogen receptor, the luminal-B subtype runs an increased risk for early relapse compared with the luminal-A subtype, even if receiving endocrine therapy. Luminal-B subtype is typically identified by high expressions of proliferation-related genes. Some novel signaling pathways are being studied to improve survival. This article reviewed the gene expression characteristics, pathological and clinical features of luminal-B breast cancer, and potential targets for treatment.
出处
《医学争鸣》
CAS
北大核心
2014年第2期10-13,共4页
Negative
基金
第四军医大学西京医院学科助推计划(XJZT10Y24)
