期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

五环三萜类化合物抗HIV研究进展 被引量：3

Advances on Pentacyclic triterpenoids in anti-HIV
原文传递
导出
摘要 为克服现有艾滋病治疗药物毒性大及易产生耐药性的缺点,近年来,不少学者以天然化合物为先导物进行结构改造,以期发现活性高、毒性小的新型抗艾滋病药物,其中,对五环三萜类化合物白桦酸、齐墩果酸、熊果酸C-3位羟基、C-28位羧基、以及C12-13位双键等基团进行结构改造的研究取得了一定进展,对治疗AIDS显示了巨大潜力。 For overcoming the toxicity and drug resistance in existing drug for theating of AIDS, the structure modifications of nature occurring component as the leading compound have been carried out by researchers, for getting high activity and low toxicity anti-AIDS drug in recent years. And in these components, some development have been achieved on the pentacyclic triterpenoids, such as reorganizating to C-3 hydroxyl, C-28 carboxyl Group and C12-13 double bond of betulinic acid and oleanolic acid and ursolic acid, which shows great potential in AIDS therapy.
作者 张丽 李群林 李灵芝
机构地区 武警后勤学院药物化学教研室 天津市职业与环境危害防制重点实验室
出处 《武警后勤学院学报（医学版）》 CAS 2014年第3期263-268,共6页 Journal of Logistics University of PAP（Medical Sciences）
基金 国家自然科学基金(81073152) 天津市科技攻关项目(12JCZDJC34700) 武警医学院面上项目(WYM201014)
关键词 人免疫缺陷病毒 五环三萜 白桦酸 齐墩果酸 HIV Pentacyclic triterpenoids Betulinic acid Oleanolic acid
分类号 R917 [医药卫生—药物分析学]
  • 相关文献

参考文献29

  • 1冯国宣,何义发,宋鄂平.抗艾滋病病毒天然产物研究现状[J].湖北民族学院学报（医学版）,2001,18(4):38-40. 被引量：6
  • 2Fujioka T,Kashiwada Y.Anti-aids agents,11.Betulinic acid and plataonic acid as anti-HIV principles from Syzigium Claviflorum,and the anti-HIV activity of structurally related triterpenoids[J].J of Nat Prod,1994,57(2):243-247.
  • 3Aiken C,Chen C H.Betulinic acid derivatives as HIV-1 an-tivirals[J].Trends Mol Med,2005,11(1):31-36.
  • 4Evers M,Poujade C,Soler F,et al.Betulinic Acid Deriva-tives:A new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action[J].J Med Chem,1996,39(5):1056-1068.
  • 5Kashiwada Y,Hashimoto F,L.Mark C,et al.Betulinic Acid and Dihydrobetulinic Acid Derivatives as Potent Anti-HIV Agents[J].J Med Chem,1996,39(5):1016-1017.
  • 6Qian K,Kou R-Y,Chen C-H,et al.Anti-AIDS agents 81.design,synthesis,and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent hiv maturation inhibitors[J].J Med Chem,2010,53(8):3133-3141.
  • 7Hshimoto F,Kashiwada Y,Cosentino LM,et al.Anti-AIDS agents-xxvii,synthesis and anti-hiv activity of betulinic acid and dihydrobetulinic acid derivatives[J].Bioorganic & Medicinal Chemistry,1997,5(12):2133-2143.
  • 8Qian K,Nakagawa-goto K,Yu DL,et al.Anti-AIDS agents 73:Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid deriv-atives[J].Bioorg Med Chem Letters,2007,17(23):6553-6557.
  • 9Kashiwada Y,Chiyo J,lkeshiro Y,et al.Synthesis and Anti-HIV activity of 3-Alkylamido-3-deoxy-betulinic acid de-rivatives[J].Chem Pharmaceut Bull,2000,48(9):1387-1390.
  • 10Sun i-C,Chen C-H Chen,Kashiwada Y,et al.Anti-AIDS agents 49.synthesis,anti-hiv,and anti-fusion activities of ic9564 analogues based on betnlinic acid[J].J Med Chem,2002,45(19):4271-4275.

二级参考文献42

  • 1刘智勇,单书香,刘林.国外抗爱滋病天然产物研究近况[J].天然产物研究与开发,1994,6(4):85-90. 被引量：7
  • 2Dasgupta TK,Pezzuto JM. Use of betulinic acid and its derivatives for inhibiting malignant melanoma growth and a method of monitoring this[ P]. W, 96/29068.1996 - 09-26.
  • 3Chang SY, Chang SY, Nohara T. Two new lupane-triterpene glycosides from leaves of Acanthoparax Koreanum [ J ] . Chem Pharm Bull, 1998,46 ( 1 ): 163 - 165.
  • 4Kuo HL, Yoshiki K, Fumio H, et al. Inventors. Betulinic acid derivatives and uses therefor[ P]. W, 96/39033. 1996 - 12 - 12.
  • 5Srivastava AK, Shakeel M, Khan AA. QSAR studies on anti HIV-1 N-subtituted betulinic acid amides[ J ]. Ind J Chem, 2002,41B(2) :436 - 439.
  • 6Sun IC, Chen CH, Kashiwada Y, et al. Anti-AIDS agents 49. synthesis, anti-HIV, and anti-fusion activities of IC9564 ana logues based on betulinic acid[ J ]. J Med Chem, 2002,45 ( 19 ):4271 - 4275.
  • 7Fujioka T,Kashiwada Y, Kilkuskic RE, et al. Anti-AIDS agents 11,betulinic acid and platonic acid as anti-HIV principles from syzigium claviflorum and the anti-HIV activity of structurally related triterpenoids [ J ]. J Nat Prod, 1994,57 (2): 243 - 247.
  • 8Pisha E, Chai H, Lee IS, et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that function by induction of apoptosis[J]. Nat Med, 1995,1 (10): 1046 - 1051.
  • 9Pezuto JM,Kosmeder JWH,Xu ZQ, et al. Prodrugs of betulinicacid derivatives for the treatment of cancer and HIV[P]. W,02/ 16395. 2001 - 08 - 18.
  • 10Evers M, Poujade C, Soler F, et al. Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific in hibitors with a new mode of action[J ]. J Med Chem, 1996,39(5):1056-1068.

共引文献87

同被引文献105

  • 1http://www.tibotec.com/content/backgrounders/www.tibotec.com/hcv_lifecycle.html.
  • 2Lew W, Chen XW, Kim CU. Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor. Curr Med Chem, 2000, 7: 663-672.
  • 3Teissier E, Penin F, Pécheur EI. Targeting cell entry of enveloped viruses as an antiviral strategy. Molecules, 2010, 16: 221-250.
  • 4Vanderlinden E, Naesens L. Emerging antiviral strategies to interfere with influenza virus entry. Med Res Rev, 2014, 34: 301-339.
  • 5Yu MR, Si LL, Wang YF, Wu YM, Yu F, Jiao PX, Shi YY, Wang H, Xiao SL, Fu G, Tian K, Wang YT, Guo ZH, Ye XS, Zhang LH, Zhou DM. Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses. J Med Chem, 2014, 57: 10058-10071.
  • 6Yu F, Wang Q, Zhang Z, Peng YY, Qiu YY, Shi YY, Zheng YX, Xiao SL, Wang H, Huang XX, Zhu LY, Chen KB, Zhao CK, Zhang CL, Yu MR, Sun DA, Zhang LH, Zhou DM. Development of oleanane-type triterpenes as a new class of HCV entry inhibitors. J Med Chem, 2013, 56: 4300-4319.
  • 7Wang H, Wang Q, Xiao SL, Yu F, Ye M, Zheng YX, Zhao CK, Sun DA, Zhang LH, Zhou DM. Elucidation of the pharmacophore of echinocystic acid, a new lead for blocking HCV entry. Eur J Med Chem, 2013, 64: 160-168.
  • 8Yu F, Peng YY, Wang Q, Shi YY, Si LL, Wang H, Zheng YX, Emily Lee, Xiao SL, Yu MR, Li YB, Zhang CL, Tang HL, Wang CG, Zhang Lihe, Zhou DM. Development of bivalent oleanane-type triterpenes as potent HCV entry inhibitors. Eur J Med Chem, 2014, 77: 258-268.
  • 9Huang L, Chen CH. Molecular targets of anti-HIV-1 triterpenes. Curr Drug Targets Infect Disord, 2002, 2: 33-36.
  • 10Zhang W, Men X, Lei P. Review on anti-tumor effect of triterpene acid compounds. J Cancer Res Ther, 2014, 10(Suppl 1): 14-19.

引证文献3

二级引证文献27

武警后勤学院学报（医学版）
2014年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部