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真核翻译延伸因子1A1在肿瘤发生和发展中作用的研究进展 被引量：3

Advances in research on the role of eukaryotic translation elongation factor 1A1 in tumorigenesis and progression
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摘要 真核翻译延伸因子1A1(eukaryotic translation elongation factor 1A1,eEF1A1)是一个在蛋白质合成过程中发挥肽链延伸作用的重要因子,在细胞生长过程中起着重要作用。研究表明,eEF1A1的作用不只局限于肽链的延伸过程,还可参与蛋白质翻译后修饰、蛋白质降解以及细胞骨架的调节等生理活动,这些非经典功能使其在细胞增殖、凋亡以及肿瘤细胞侵袭和转移等方面均发挥了重要作用,干扰eEF1A1的表达可以影响肿瘤化疗的敏感性,eEF1A1可能成为一个潜在的肿瘤防治靶点。本文对近年来关于eEF1A1在肿瘤发生和发展中作用的研究进展进行简要综述。 Eukaryotic translation elongation factor 1A1 （eEF1A1） is an important factor in polypeptide chain elongation and plays an important role in cell growth. The function of eEF1A1 is not only limited in polypeptide chain elongation but also participates in protein post-translational modification, protein degradation, regulation of cytoskeleton and other physiological activities. Through these non-canonical functions, eEF1A1 plays an important role in proliferation, apoptosis, invasion and metastasis of tumor cells. Moreover, knockdown of eEF1A1 can enhance the chemosensitivity of tumor cells. These results indicate that eEF1A1 may become a potential target for prevention and treatment of cancer. This article reviews the latest advances in potential role of eEF1A1 in tumorigenesis and progression.
作者 晏琛 邵江华
机构地区 南昌大学第二附属医院肝胆外科
出处 《肿瘤》 CAS CSCD 北大核心 2014年第4期378-382,共5页 Tumor
基金 国家自然科学基金资助项目(编号:81060196) 江西省科技计划项目(编号:20121BBG70029) 江西省高等学校科技落地计划项目(编号:12053)
关键词 肿瘤 细胞增殖 细胞凋亡 肿瘤转移 eEF1A1 Neoplasms Cell proliferation Apoptosis Neoplasm metastasis Eukaryotic translation elongation factor 1A1
分类号 R730.231 [医药卫生—肿瘤]
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参考文献38

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二级参考文献65

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共引文献24

同被引文献64

  • 1黄志峰,李得堂.补气类中药抗肿瘤的研究现状[J].中医肿瘤学杂志,2019,0(5):78-81. 被引量：11
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  • 3Soares DC, Barlow PN, Newbery HJ, et al. Structuralmodels of human eEFl Al and eEFl A2 reveal twodistinct surface clusters of sequence variation andpotential differences in phosphorylation[J]. PLoSOne, 2009,4(7):e6315.
  • 4Kapp LD, Lorsch JR. The molecular mechanicsof eukaryotic translation[J]. Annu Rev Biochem,2004(73):657-704.
  • 5Caraglia M, Budillon A,Vitale C, et al. Modulationof molecular mechanisms involved in proteinsynthesis machinery as a new tool for the controlof cell proliferation[J]. Eur J Biochem, 2000,267(13):3919-3936.
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二级引证文献5

肿瘤
2014年 第4期

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