摘要
目的探讨急性脑梗死患者CD62E＋微颗粒水平与其病情严重程度、预后及血管危险因素的相关性。方法选取自2013年1月至9月珠江医院神经内科住院诊疗的70例急性脑梗死患者为研究对象（急性脑梗死组），按照美国国立卫生研究院卒中量表（NIHSS）评分评定病情严重程度，以Barthel指数（BI）评分评定预后，并常规行血脂、血糖、尿酸、纤维蛋白原（Fr01、同型半胱氨酸（Hcy）、C反应蛋白（CgP）、脂蛋白相关磷脂酶A2（Lp．PLA2）检查。选择同期就诊的70例非脑梗死患者为对照组。流式细胞术检测2组对象外周血CD62E＋微颗粒水平，统计学方法分析CD62E＋微颗粒水平与疾病严重程度、预后及血管危险因素的相关性。结果急性脑梗死组血液中CD62E＋微颗粒水平[（1．55±0．67）个／μL]较对照组[（1．01±0．66）个／μL]明显增高，并且NIHSS〉5分组CD62E＋微颗粒水平[（2．03±0．61）个／μL]明显高于NIHSS≤5分组[（1．25＋0．37）个／μL]，差异均有统计学意义（P〈0．05）。Spearman相关性分析显示，CD62E＋微颗粒水平与脑梗死严重程度（NIHSS评分）及Lp-PLA2水平呈明显正相关关系（F0．537，P=-0．000；r=0．327，P=-0．006），与反映预后的BI评分呈明显负相关关系（F=0．634，P=-0．000），而与其他血管危险因素无明显相关性。结论CD62E＋微颗粒水平有作为反映急性脑梗死病情严重程度及预后的生物学指标的潜在临床应用价值，且其与LO-PLA2的正相关性提示CD62E＋微颗粒水平与动脉粥样硬化斑块的稳定性相关。
Objective To explore the level of CD62E＋ endothelial microparticles in acute cerebral infarction patients and its relationship with vascular risk factors, degree of severity and prognosis. Methods Seventy patients with acute cerebral infarction and 70 non- cerebral infarction patients （controls）, admitted to our hospital from January 2013 to September 2013, were selected in our study; U.S. national institutes of health stroke scale （NIHSS） was performed to evaluate the degree of severity; Barthel index （131） was used to evaluate the prognosis; the levels of blood lipids, blood glucose, uric acid, fibrinogen （FIB）, homocysteine （Hey）, C-reactive protein （CRP） and lipoprotein-associated phospholipase A2 （Lp-PLA2） were routinely measured; CD62E＋ levels were detected by flow cytometry, and the relationships of CD62E＋ level with vascular risk factors, degree of disease and prognosis were analyzed. Results The blood CD62E＋ level of patients with acute cerebral infarction （[1.55 ±0.67] microparticle/μL） was significantly higher than that in the control group （[1.01±0.66] microparticle/μL, P〈0.05）; CD62E＋ level in patients with NIHSS scores〉5 （[2.03±0.61] microparticle/μL） was significantly higher than that in patients with NIHSS scores ≤ 5 （[1.25±0.37] microparticle/μL, P〈0.05）. Spearman correlation analysis showed that CD62E＋ level was significantly correlated with the stroke severity （NHISS scores, r=0.537, P=-0.000） and lipoprotein-associated phospholipase A2 （Lp-PLA2） level （r= 0.327, P=0.006）, and negatively correlated with prognosis indicator （r=-0.634, P=0.000）; other factorsshowed no significant correlation. Conclusion CD62E＋ microparticle can reflect the severity and prognosis of acute brain infarction, and it may be an important biological marker for clinical application. Besides, the correlation between Lp-PLA2 and CD62E＋ means that the level ofCD62E＋ micro particles is associated with the stability of atherosclerotic plaques.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2014年第4期388-392,共5页
Chinese Journal of Neuromedicine
关键词
急性脑梗死
内皮微颗粒
CD62E
病情
预后
血管危险因素
Acute cerebral infarction
Endothelial microparticles
CD62E＋
Degree of severity
Prognosis
Risk factor
