摘要
目的探讨可溶性髓样细胞触发受体-1(sTREM-1)对糖尿病合并肺部感染的早期诊断价值。方法以2008年7月至2013年6月收治的2型糖尿病并发肺部感染患者79例作为肺部感染组,单纯随机选取同期无并发肺部感染的2型糖尿病患者80例作为对照组,检测2组sTREM-1和降钙素原(PCT)水平。结果肺部感染组sTREM-1和PCT水平均明显高于对照组(P<0.01);sTREM-1和PCT在2型糖尿病患者中早期诊断肺部感染的受试者工作特征曲线(ROC曲线)下面积分别为0.932和0.921,sTREM-1的敏感性和特异性分别为92.4%和86.3%,PCT的敏感性和特异性分别为81.0%和85.0%。结论血清sTREM-1和PCT是2型糖尿病合并肺部感染早期诊断的较好指标,具有较高的敏感性和特异性,sTREM-1优于PCT。
Objective To investigate the early diagnostic value of soluble triggering receptor expressed on myeloid cells-1 （sTREM-1） in type 2 diabetic patients with pneumonia. Methods 79 cases of type 2 diabetic patients with pneumonia between July 2008 and June 2013 were chosen as the pneumonia group. In the same period,80 cases of type 2 diabetes mellitus patients without pneumonia were randomly selected as the control group. Levels of sTREM-1 and procalcitonin （PCT） were measured. Results The levels of sTREM-1 and PCT were significant higher in pneumonia group than those in control group （P〈0.01）. The area under the curve （AUC） of sTREM-1 and PCT were 0. 932 and 0. 921,respectively. The sensibility and specificity of sTREM-1 were 92.4% and 86.3% ,while the sensibility and specificity of PCT were 81.0% and 85.0%. Conclusion Serum sTREM-1 and PCT are good biomarkers for early diagnosis of pneumonia in type 2 diabetic patients, and both have higher sensitivity and specificity, while sTREM-1 is better than PCT.
出处
《国际检验医学杂志》
CAS
2014年第7期822-823,826,共3页
International Journal of Laboratory Medicine
