摘要
目的 探讨无抽搐电休克治疗（MECT）对青少年精神分裂症患者执行功能的影响.方法 选取无锡市精神卫生中心2010年3月～ 2012年12月21例青少年精神分裂症患者合并MECT治疗纳入研究组,选取同一时间22例单一非典型抗精神病药物治疗者纳入对照组.在治疗前后均采用威斯康星卡片分类测验（Wisconsin card sorting test, WCST）、阳性和阴性综合征量表（PANSS）对患者的执行功能及临床症状进行评价.结果 两组治疗前PANSS、WCST评分比较,差异无统计学意义（P＞0.05）.研究组治疗后PANSS总分及各因子分比治疗前显著降低（P＜0.01）,对照组治疗后PANSS总分和一般精神病理分比治疗前显著降低（P＜0.05）;组间比较,治疗后研究组PANSS一般精神病理因子分显著低于对照组（t =2.07,P＜0.05）;研究组WCST的总应答数及持续性错误低于对照组（t=2.43,t=2.17,P＜0.05）.结论 合并MECT治疗对青少年精神分裂症患者执行功能无明显损害,能提高治疗的疗效.
Objective To explore the effect of MECT on executive function of adolescent patients with schizophrenia. Methods 21 adolescent patients with schizophrenia treated with MECT from Mar 2010 to Dec 2012 in Wuxi Mental Health Center were involved in study group, and 22 adolescent patients with schizophrenia treated with one atypical antipsyehotie at the same period of time were involved in control group. Patients in the two groups were assessed with Wisconsin Card Sorting Test （WCST） and Positive and Negative Symptom Scale （PANSS） at baseline and at the end of the treatment to evaluate the change of executive function and clinical severity. Results There were no significant differences in score of WCST and PANSS between two groups at baseline （ P 〉 0.05 ）, At the end of the treatment, total score and factor scores of PANSS in study group, as well as total score of PANSS and factor score of general psychopathology in control group decreased significantly when compared with baseline. Factor score of general psychopathology in PANSS, trails administered and preservative errors in WCST in study group were significantly lower than those in control group （ t = 2.07, 2.43 and 2.17 respectively ; P 〈 0.05 ）. Conclusion MECT has no negative effect on executive function in adolescent patients with schizophrenia. It can elevate the therapeutic effect of antipsyehoties when used as an adjunctive therapy.
出处
《精神医学杂志》
2014年第1期30-32,共3页
Journal of Psychiatry
关键词
无抽搐电休克治疗
青少年精神分裂症
执行功能
Modified electroconvulsive therapy （MECT） Adolescent Schizophrenia Executive function
