摘要
目的建立采用抑制型离子色谱法测定乳酸钠林格注射液中氯化钠、氯化钾和氯化钙含量的方法。方法色谱条件为IonPacCS12A色谱柱（4mm×250mm），淋洗液为25mmol·L^-1甲烷磺酸溶液，流量1．0mL·min^-1；抑制器为CSRS 3004mm self-Regenerating Suppressor；抑制电流74mA；电导检测器。结果氯化钠、氯化钾和氯化钙线性范围分别为2．076～207．6μg·mL^-1（r=0．9999）、2．144-214．4μg·mL^-1（r=0．9999）和3．260～326．0μg·mL^-1（r=0．9999），回收率分别为100．2％、100．9％和99．4％。结论本方法准确、简便，可用于乳酸钠林格注射液的质量控制。
OBJECTIVE To establish a method for determination of sodium chloride, potassium chloride and calcium chloride content in Sodium Lactate Ringer＇s Injection by suppressed IC. METHODS IonPac CS 12A column（4mm ×250mm） was used with 25 mmol · L^-1 methanesulfonic acid solution as eluting solution. The flow rate was 1.0mL· min^-1 .The Suppressor was CSRS 3004mm self-Regenerating Suppressor. and Suppress current was 90mA. Electrolytic conductivity detector was used. RESULTS The linear ranges of sodium chloride, potassium chloride and calcium chloride were 2. 076 - 207.6μg · mL-l（ r = 0. 9999 ）, 2. 144 -214.41xg ~ mL^-1 （r = 0. 9999 ）and 3. 260 -326. 01μg · mL^-1 （r =0. 9999）. The average recoveries of sodium chloride,potassium chloride and calcium chloride were 100. 2% ,100. 9% and 99.4%. CONCLUSION The method is accurate ,simple,and can be used for the quality control of sodium lactate Ringer＇s injection.
出处
《海峡药学》
2014年第3期47-49,共3页
Strait Pharmaceutical Journal
关键词
离子色谱法
乳酸钠林格注射液
氯化钠
氯化钾
氯化钙
IC
Sodium Lactate Ringer＇s Injection
Sodium chloride
Potassium chloride
Calcium chloride
