摘要
目的研究维生素D与骨密度的相关性。方法调查248名自由居住在上海的中老年人,女性128名,男性120名,年龄在40到90之间,他们都是从人口基数中随机选入的。分别测量选入对象的全身骨密度和血清中25(OH)D的含量,分析两者之间的相关性。结果研究对象的平均年龄70.03±11.44岁,其中男性的平均年龄为70.96±12.22岁,女性的平均年龄为69.16±10.62岁。研究对象的平均25(OH)D的总量浓度为13.733±6.894 ng/ml;平均25(OH)D2的浓度为1.672±1.577 ng/ml,平均25(OH)D3的浓度为12.057±6.631 ng/ml。其中男性平均25(OH)D的总量浓度为14.258±5.557 ng/ml;平均25(OH)D2的浓度为1.580±1.548 ng/ml,平均25(OH)D3的浓度为12.710±5.440 ng/ml。女性平均25(OH)D的总量浓度为13.241±7.937 ng/ml;平均25(OH)D2的浓度为1.758±1.604 ng/ml,平均25(OH)D3的浓度为11.445±7.550 ng/ml。研究对象中97%(n=241)25(OH)D的浓度小于30 ng/ml;其中男性中99%的人(n=119)25(OH)D的浓度小于30 ng/ml;女性中95%的人(n=122)25(OH)D的浓度小于30 ng/ml。研究对象中83%(n=206)的人伴有股骨颈骨质疏松;86%的人(n=214)伴有腰椎的骨质疏松。其中男性中82%的人(n=98)伴有股骨颈骨质疏松,84.2%的人(n=101)伴有腰椎的骨质疏松。女性中84.4%的人(n=108)伴有股骨颈骨质疏松,88.3%的人(n=113)伴有腰椎的骨质疏松。在多变量的数据分析里,校正了年龄、体重指数的差异后,发现25(OH)D与骨密度之间存在一定关系(见表3、4、5)。结论在中国上海健康中老年人群中存在严重的维生素D不足和缺乏状况,维生素D的状态与骨密度可能存在正性相关,必须进一步进行大样本的研究来探讨维生素D与骨质疏松症及骨折的关系。
Objective To investigate the correlation between vitamin D and bone mineral density （ BMD） .Methods A total of 248 middle-aged and elder Shanghai residents, including 128 women and 128 men, aged between 40 and 90 years old, were randomly selected from participants of a population-based study.BMD of the whole body and serum 25-（ OH ） D level were detected.The correlation between those was analyzed.Results The average age of all the subjects was 70.03 ±11.44 years old, an average age of 70.96 ±12.22 years old in men and 69.16 ±10.62 years old in women.The total concentration of 25-（ OH） D in all the subjects was 13.733 ±6.894 ng/ml.The average concentration of 25-（ OH） D2 and 25-（ OH） D3 in all subjects was 1.672 ± 1.577 ng/ml and 12.057 ±6.631 ng/ml, respectively.In men, the concentration of total 25-（ OH） D, 25-（ OH） D2 , and 25-（ OH） D3 was 14.258 ±5.557 ng/ml, 1.580 ±1.548 ng/ml, and 12.710 ±5.440 ng/ml, respectively.The concentration in women was 13.241 ±7.937 ng/ml, 1.758 ±1.604 ng/ml, and 11.445 ±7.550 ng/ml, respectively.Among all the subjects, 83%（n=206） had femoral neck osteoporosis, and 86% （ n =214 ） had lumbar osteoporosis.In men, 82% （ n =98 ） had femoral neck osteoporosis, and 84.2%（n=101） had lumbar osteoporosis.In women, 84.4% （n=108） had femoral neck osteoporosis, and＆amp;nbsp;88.3% （n=113） had lumbar osteoporosis.After adjusting for age and body mass index difference in multivariate data analysis, 25-（ OH） D was correlated with BMD to some extent.Conclusion The insufficiency and deficiency of vitamin D is severe in the healthy elderly population in Shanghai.Vitamin D may be positively correlated with BMD.Further large sample research must be performed to explore the relationship between vitamin D and osteoporosis and the fracture.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2014年第3期292-296,共5页
Chinese Journal of Osteoporosis
关键词
维生素D
骨密度
骨质疏松
Vitamin D
Bone mineral density
Osteoporosis
