摘要
目的探讨中青年和老年女性乳腺癌患者的临床特征。方法选择2004年月至2008年12月间手术治疗的180例乳腺癌患者为研究对象,根据年龄分为老年组(>60岁)90例,中青年组(≤60岁)90例。比较两组患者的临床资料及治疗效果。结果两组患者体重指数(BMI)和手术方式比较,差异无统计学意义(P>0.05)。与中青年组相比,老年组患者肿瘤分期晚、并发症发生率高,且化疗比例小、化疗耐受性差及复诊率低,差异有统计学意义(P<0.05)。老年组患者雌激素受体(ER)和孕激素受体(PR)阳性率高于中青年组,人表皮生长因子受体2(HER2)阳性率低于中青年组低,差异有统计学意义(P<0.05)。两组患者5年生存率比较,差异无统计学意义(P>0.05)。结论中青年与老年乳腺癌患者临床和病理特征存在差异,在诊疗过程中提高早期诊断率,对不同年龄段患者采取针对性治疗并督促其坚持完成化疗,加强术后随访,可提高患者生活质量,改善生存率。
Objective To explore the clinical features of young and middle-aged and elderly pa- tients with breast cancer. Methods 180 breast cancer patients underwent surgery from January 2004 to De- cember 2008 were chosen. According to the age, these patients were divided into old age group（ 〉 60 years） and young and middle-aged group（ ~〈60 years）. Clinical data and follow-up results were compared between the two groups. Results There was no significant difference in body mass index （BMI） and operation method between the two groups （ P 〉 0. 05 ）. Compared with young and middle-aged group, patients in old age group were in later tumor stage, higher incidence of complications, less proportion of chemotherapy and toler- ance, and lower follow-up rate, and there was significant difference between the two groups （ P 〈 0. 05 ）. The positive rate of estrogen receptor（ER） and progesterone receptor（PR） in old age group was higher than that in young and middle-aged group, but the positive rate of human epidermal growth factor receptor 2 （ HER2 ） in old age group was lower than that in young and middle-aged group, and there was significant difference（ P 〈 0. 05 ）. There was no significant difference in the 5 year survival rate between the two groups （ P 〉 0. 05 ）. Conclusions Compared with young and middle-aged patients, the elderly patients with breast cancer have unique clinical and pathological features and early diagnosis should he paid attention to them. Patients should be given unique therapy according to age and be supervised to complete chemotherapy. The follow-up of patients after operation should be strengthen in order to improve the quality of life and increase the surviv- al rate.
出处
《中国肿瘤临床与康复》
2014年第3期293-295,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
中青年
老年
乳腺肿瘤
临床特征
Young and middle-aged
Aged
Breast neoplasms
Clinical features
