摘要
心脑血管疾病死亡已居全病因死亡的第一位,如何降低脑卒中的死亡和残疾,是目前研究的热点。丁苯酞是目前我国自主研发的国家级化学Ⅰ类新药,通过重构脑缺血区微循环、抑制神经细胞凋亡、保护线粒体、清除自由基、抗血小板聚集、抑制血栓形成、降低炎症反应、保护血管内皮细胞等作用,阻断缺血性脑损伤的多个病理环节,改善急性缺血性脑卒中神经功能缺损,提高患者生活能力和生存质量。本文重点阐述丁苯酞对急性缺血性脑卒中的作用和保护机制。
Mortality caused by cardiovascular and cerebrovascular diseases has been ranked the first in all causes of death, and how to reduce mortality and disability of patients with stroke is a hot topic at present. Butylphthalide is a national chemical class I drug which is researched and developed by Chinese researchers. It＇ s main roles includes remodeling the microcireulation of ischemic areas, restraining the apoptosis of nerve cells, protecting mitochondria and vascular endothelial cells, scavenging free radicals, inhibiting platelet aggregation and thrombosis and reducing the inflammatory response. Butylphthalide could block multiple pathological links in ischemie brain damage, reduce ischemia penumbra brain tissue volume, and improve the acute ischemic cerebral apoplexy nerve functional defects to improve the ability and quality of life of the patients. This paper reviewed the roles and protective mechanisms of Butylphthalid in patients with acute ischemic stroke.
出处
《中华脑血管病杂志（电子版）》
2013年第6期40-43,共4页
Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词
丁苯酞
急性缺血性脑卒中
作用
保护机制
Butylphthalide
Acute ischemic stroke
Function
Protective mechanism
