期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

大鼠脑缺血再灌注c-fos表达与神经细胞凋亡关系研究 被引量：3

在线阅读 下载PDF
导出
摘要 目的探讨大鼠脑缺血再灌注后脑组织中c-fos表达水平与神经细胞凋亡的关系。方法采用大脑中动脉线栓法制备局灶性脑缺血再灌注模型,参考Longa的5分制法在大鼠麻醉清醒后进行评分;应用免疫组化、TUNEL法检测大鼠脑缺血再灌注后脑组织中c-fos表达水平及神经细胞凋亡情况。结果大鼠脑缺血再灌注后缺血脑组织中c-fos表达明显增加(P<0.01),于缺血再灌注12小时后达高峰,且神经细胞凋亡数明显增加(P<0.01)。结论脑缺血再灌注后神经细胞c-fos表达水平增加,并参与神经细胞凋亡机制。
作者 陈江君 陈军 鲁雅琴 王颖 杨奎 蒋珍秀
机构地区 兰州大学第一医院
出处 《卫生职业教育》 2014年第6期89-90,共2页 HEALTH VOCATIONAL EDUCATION
关键词 大鼠脑缺血再灌注 C-FOS表达 神经细胞凋亡
分类号 G424.31 [文化科学—课程与教学论]
  • 相关文献

参考文献10

  • 1蔡紫峰,杨卓.脑缺血损伤的研究进展[J].继续医学教育,2004,18(4):53-55. 被引量：16
  • 2Koennecke HC. Editorial comment-'challenging the concept of adynamic penumbra in acute ischemic stroke [J]. Stroke,2003(10) : 24-34.
  • 3Nagasawa H,Kogttre K. Correlation between cerebral blood flow and hlstologic changes in a new rat model of middle cerebral artery occlusion [J].Stroke, 2000(3 ): 84-91.
  • 4Longa E Z, Weinstein P R, Carlson S, et al. Reversible middle cere- bralatery occlusion[J].Stroke, 1998( 1 ) : 84-91.
  • 5Espinoza M I,Parer J T.Mechanisms of asphyxial brain damage,and possible pharmacologic interventions, in the fetus[J].Am J Obstet Gynecol, 2005,164 (6) : 1582-1589.
  • 6Chandrasekar B ,Mnmmldi S,Mahimainathan Let al. Interhuk in-18- induced human coronary artery smooth muscle eellmigration is dependent on c-foe aad AP-1-mediated matrix metallop roteinase-9 expression and is inhibited by atorvastatin[J]. J Bid Chem,2006,281(22) : 15099.
  • 7Morgan J I,Curran T. Stimulus transcription coupling in the nervous system: involvement d the inducible protconcogenes fos and jun [J].Ann Rev Neurosci, 1991(14) :421-451.
  • 8Rau SW, Dubal DB. Est radiol differentially regulates c-Foe after focal cerebral ischemia[J]. J Neurosci,2003,23(33) :10487-10494.
  • 9Schbitz WR,Schade H,Heiland S,et al. Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI [J].Stroke, 2004 (5) : 1175-1179.
  • 10Whitfield J,Neame SJ,Paquet Let al.Dominant negativec Jun pro- motes neuronal survival by reducing BIM expression and inhibiting mito- chondrial cytochrcmec release [J].Neuron, 2001,29(3) :629-643.

二级参考文献20

  • 1MACDONALD RL,STOODLEY M.Pathophysiology of cerebral ischemia[J].Neurol Med Chir(Tokyo),1998,38(1):1-1.
  • 2KINOUCHI H,KAMIL H.Role of superoxide dismutase in ischemic brain injury:a study using SOD-L transgenic mice[J].Cell Mol Neurobiol,1998,18(6):609-620.
  • 3AL NITA D,NITA V,SPULBER S.Oxidative damage following cerebral ischemia depends on reperfusion-a biochemical study in rat[J].J Cell Mol Med,2001,5(2):163-170.
  • 4MACMAHON S,PETO R,CUTLER J,et al.Blood pressure,stroke and coronary heart diserse[J].Lancet,1990,335(6):765-774.
  • 5NUNES JP,FRIA MDS,POLONIA JJ.Acute ischemic stroke during ambulatory blood pressure monitoring[J].Laucet,1992,339(2):113-114.
  • 6MORFIS L,SCHWARTZ RS,PORLOS RS,et al.Blood pressure changes in acute cerebralinfarction and hemorrhage[J].Stroke,1997,28(7):1401-1405.
  • 7LIP GHY,ZARIFIS J,FAROOQIS E,et al. Ambulatory blood pressure monitoring in acute stroke[J].Stroke,1997,28(1):31-35.
  • 8OLSSON T,MARKLUND N,GUSTAFSON Y,et al.Abnormalities at different levels of the hypothalamic-pituitary-adrenocortical axis early after stroke[J].Stroke,1992,23(11):1573-1576.
  • 9HARPER G,FOTHER BY MD,PANAYIOTON BJ,et al.The change in blood pressure after acute stroke effect with 24h ambulatory monitoring[J].J Intern Med,1994,235(4):343-346.
  • 10NAVER HK,BLOMSTRAND C,WALLIN G.Reduced heart rate variability after right-sided stroke[J].Stroke,1996,27:247-251.

共引文献15

同被引文献53

引证文献3

二级引证文献7

卫生职业教育
2014年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部