摘要
目的探讨脊索样胶质瘤的临床病理学特征、免疫表型、诊断及鉴别诊断。方法对6例脊索样胶质瘤患者的临床、影像学及组织病理学资料进行回顾分析。结果6例患者中女性5例，男性1例，发病年龄23～58岁，平均年龄40．7岁。临床主要症状为记忆力减退、头痛、呕吐和嗜睡等，5例女性患者伴有不同程度的月经失调。组织学特征为黏液基质中可见团状或条索状的GFAP阳性的上皮样瘤细胞，伴有多少不等的淋巴浆细胞浸润。免疫组化：瘤细胞GFAP、vimentin、EMA和S-100均（＋）；且黏液基质PAS（＋）。结论脊索样胶质瘤位于第三脑室及周围区，是中枢神经系统独特的罕见肿瘤，结合组织学形态、免疫组化及组织化学染色可明确诊断。
Objective To investigate the clinicopathologieal characteristics, the immunological expression, diagnosis and differential diagnosis on the ehordoid glioma, in order to improve the diagnosis level of the tumor. Methods The data of clinical imaging and histopathology were reviewed in 7 cases of chordoid glioma. Results Of 7 cases, 5 cases were female and 2 cases were male, aged 23 to 58 years （mean 40. 7 years）. The main clinical symptoms were memory loss, headache, vomiting and lethargy. 5 cases of female patients complicated with varying degrees of irregular menstruation. The histological features showed cords of GFAP positive epithelioid tumor cells in the background of myxoid matrix, lymphocytes and plasma cell infiltration. All the 7 cases expressed GFAP, VIM, EMA, and S-IO0, and mucous matrix was positive for PAS. Conclusions Chordoid glioma located in the third ventricle and the surrounding area is a unique rare tumor of the central nervous system, and combination of histomorphology, immunohistochemical and histoehemical staining can make a definite diagnosis.
出处
《诊断病理学杂志》
CSCD
北大核心
2014年第3期138-141,共4页
Chinese Journal of Diagnostic Pathology
关键词
脊索样胶质瘤
免疫组化
组织学
Chordoid glioma
Immunohistochemistry
Histology
