摘要
目的通过检测过敏性紫癜患者外周血中IL-17,IL-23及维甲酸受体相关孤儿受体γt(ROR-γt)水平变化,探讨IL-23/IL-17轴在过敏性紫癜中的作用。方法选择过敏性紫癜初发患者30例作为研究对象,30例健康正常人为对照组。采用酶联免疫吸附法检测,比较两组血清中IL-23,IL-17及ROR-γt水平的变化。结果过敏性紫癜组IL-17,IL-23及ROR-γt的水平分别为(15.19±4.2)pg/mL、(14.11±6.82)pg/mL、(60.45±17.83)pg/mL。健康对照组IL-17,IL-23及ROR-γt的水平分别为(11.30±4.73)pg/mL、(8.50±4.89)pg/mL、(40.75±15.44)pg/mL。过敏性紫癜组IL-17,IL-23及ROR-γt水平较健康对照组明显升高,差异具有统计学意义(P<0.05)。结论 IL-23/IL-17轴在过敏性紫癜的致病过程中发挥重要作用。
Objective To investigate the relationship between anaphylactoid purpura and IL-23/IL-17 related axes by quantitating the level of IL-23/IL-17 axes related factors including IL-17,IL-23 and retinoid-related orphan receptor γt（ROR-γt）. Methods Serum level of IL-17,IL-23 and ROR-γt was detected in 30 anaphylactoid purpnra patients and 30 normal controls via enzyme linked immunosorbent assay（ELISA）. Results The serum level of IL-17, IL-23 and ROR-γt was respectively（ 15. 19 ± 4.2）pg/mL, （14. 11 ± 6. 82）pg/mL, （60.45 ±17.83） pg/mL in patients with purpura, compared to（11.30 ±4.73） pg/mL, （8.50±4.89） pg/mL and （40.75 ± 15.44） pg/mL in the controls （ P 〈 0.05 ）. Conclusion IL-23/IL-17 axes may be related to the pathological processes of anaphylaetoid purpura.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第3期260-262,共3页
The Chinese Journal of Dermatovenereology
