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Aurora A激酶与妇科肿瘤 被引量：1

Aurora A kinase and gynecological tumors
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摘要 Aurora A是调控细胞周期有序进展的重要丝/苏氨酸激酶,严格依赖细胞周期参与细胞的有丝分裂进程.AURKA基因的单核苷酸多态性（SNP）及其编码产物Aurora A激酶的异常表达与卵巢癌、子宫内膜癌、宫颈癌及子宫肉瘤等妇科肿瘤的形成、发展和预后密切相关,显示Aurora A已成为妇科肿瘤靶向治疗的理想靶点. Aurora A is a key serine/threonine kinase regulating cell cycle,which is involved in various procedures of mitosis,strictly depending on cell cycle.The single nucleotide pelymorphisms （SNP） of AURKA gene and the aberrant expression of its encoding product Aurora A kinase are often closely related with the tumorigenesis,progression and prognosis of gynecological tumors,such as ovarian cancer,endometrial cancer,cervical cancer and sarcoma of uterus.Aurora A has become an ideal target for the targeted therapy of gynecological tumors.
作者 王恺越 周怀君
机构地区 南京医科大学鼓楼临床医学院
出处 《国际肿瘤学杂志》 CAS 2014年第2期117-120,共4页 Journal of International Oncology
关键词 卵巢肿瘤 子宫内膜肿瘤 宫颈肿瘤 AURORA A激酶 Ovarian neoplasms Endometrial neoplasms Cervical neoplasms Aurora A kinase
分类号 R737.3 [医药卫生—肿瘤]
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参考文献25

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  • 2Karthigeyan D, Prasad SB, Shandilya J, et al. Biology of Aurora A kinase: implications in cancer manifestation and therapy[J]. Med Res Rev, 2011, 31(5): 757-793.
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  • 5EwartToland A, Dai Q, Gao YT, et al. AuroraA/STK15 T+91A is a general low penetrance cancer susceptibility gene: a metaanalysis of multiple cancer types[J].Carcinogenesis.2005, 26(8):1368-1373.
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国际肿瘤学杂志
2014年 第2期

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