摘要
药物是一把双刃剑,既可治疗疾病也可导致肾脏等器官损伤。有效循环血量不足、原有肾脏损害、老年人、联合使用肾毒性药物是药物性肾损伤的易感因素。药物性肾损伤早期可无明显症状、体征,或仅表现为尿中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子-1、白介素-18等生物标志物的异常。在用药过程中定期检测上述指标,有助于早期发现药物性肾损伤。熟悉药物的特性和不良反应以及患者的身体状态、严格掌握药物适应证、坚持合理用药,可预防或减少药物性肾损伤。
Drugs are a double-edged sword, which can both treat the disease and cause damage to kidney and other organs. The predisposing factors of drug-induced renal injury include lack of effective volume of circulating blood, the original kidney damage, the elderly, and the joint use of nephrotoxic drugs. Early drug-induced renal injury may not show obvious symptoms, signs, or only show abnormal levels of biomarkers such as urinary neutrophil gelatinase-associated lipocalin （NGAL）, kidney injury molecule-1 （Kim-1）, and interleukin-18 （IL-18 ）, etc. During the course of medication, regular test of these indicators will help early detection of drug-induced renal injury. To prevent or reduce drug-induced renal injury, we should be familiar with the drug features, adverse drug reactions as well as the patients＆#39; physical condition, strictly control the medication indications, and adhere to rational use of drugs.
出处
《中华肾病研究电子杂志》
2013年第3期16-19,共4页
Chinese Journal of Kidney Disease Investigation（Electronic Edition）
关键词
药物
急性肾损伤
易感因素
预防
Drugs
Acute kidney injury
Predisposing factor
Prevention
