摘要
目的研究万古霉素和去甲万古霉素所致的白细胞减少的临床特点。方法收集我院2008年1月至2013年3月发生的万古霉素及去甲万古霉素相关的白细胞减少病例,总结用药剂量、发生时间、不良反应症状及转归。结果共收集与万古霉素或去甲万古霉素相关的白细胞减少11例。患者发生白细胞减少不良反应的中位数时间为用药后14 d,经过停药及对症治疗后所有患者在1周内恢复,中位数时间为3 d。结论万古霉素及去甲万古霉素可以引起白细胞减少的不良反应,其机制与免疫介导或骨髓抑制有关,停药并经对症治疗后可恢复。
Objective To research the characteristics of leukopenia induced by vancomycin or norvancomy- cin. Methods The leukopenia cases induce by vancomycin or norvancomycin were collected from January 2008 to March 2013. The dosage, occurrence time, the manifestation and the consequence of adverse reaitions were summa- rized. Results Eleven cases were collected. The median of the occurrence time was 14 days. All patients recovered within 1 week after discontinuation and symptomatic treatment, the median time was 3 days. Conclusion Vancomycin and norvancomycin can induce leucocytopenia, and the mechanism may be related to immune media reaction or bone marrow depression, and the reaction is reversible.
出处
《实用药物与临床》
CAS
2014年第1期79-81,共3页
Practical Pharmacy and Clinical Remedies
