摘要
目的:研究晚期卵巢上皮癌增殖细胞核抗原(proliferatingcellnuclearantigenPCNA的表达与化疗效果的关系。方法:选择28例Ⅲ/Ⅳ期上皮性卵巢癌手术后继续行6个疗程以上化疗有效者及28例与之相匹配的化疗无效者手术时的卵巢癌标本,以免疫组化SP法检测PCNA的表达。结果化疗无效组与化疗有效组PCNA表达强度分别为32.14±19.27%23.18±16.38%,差异显著P<0.05。结论:PCNA在化疗反应不同的上皮性卵巢癌中表达不同,有可能成为卵巢癌化疗效果的预测指标。
Objective:The current study was designed to investigate the relationship between t he proliferating cell nuclear antigen(PCNA)expression and the effect of chemoth erapy in the patients with advanced e pithelial ovarian cancer.Methods:The samples were selected at epithelial ovarian cancer StageⅢ/Ⅳ,who received more than 6courses of postoperational chemotherapy,and showed effective(chemotherapy-effective group,28c ases).Immunohistochemical SP method was used to detect the expression of PCNA protein.Result:The expressions of PCNA in chemotherapy-effective and chemotherapy-ineffective were 32.14±19.27%,23.18±16.38%(P<0.05),respectively.Conclusion:The expression of PCNA were different in epithelial ovarian cancer with different response to chemotherapy,and it may serve as a predicting factor of chemotherapy efficiency i n epithelial ovarian cancer.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2001年第2期195-196,共2页
Chinese Journal of Cancer
关键词
卵巢上皮癌
药物治疗
增殖细胞核抗原
Proliferating cell nuclear antigen
Ovarian neoplasms
Chemotherapy e fficiency
