摘要
[目的]研究天然药物紫锥菊中菊苣酸在胃肠道环境下的稳定性。[方法]选择不同pH溶液与大鼠胃肠道内容物溶液,采用HPLC-UV方法,检测菊苣酸在各种溶液中的含量变化。[结果]经过4 h的孵育,大鼠大肠内容物和小肠内容物对菊苣酸无显著影响(P>0.05),而菊苣酸在胃内容物中的降解率为36%。在不同的pH环境中,菊苣酸相对稳定。[结论]菊苣酸在不同pH条件及小肠、大肠内容物中相对稳定,而在胃中有一定程度的降解,推测酶类可能是引起其降解的主要原因。
[ Objective ] To investigate the stability of cichoric acid in gastrointestinal tract. [ Method ] Under different pH value and rat diges- tive fluid, the quantification of cichoric acid was determined by a sensitive HPLC - UV method. [ Result] After 4 h incubation, the large and small gut digestive fluid of rats have no significant effects on cichoric acid, the degradation rate of cichoric acid in digestive fluid is 36%. The cichoric acid is relatively stable under different pH value. [ Conclusion] Compared with the two results, it presented that the drug was stable in the chemical （pH） conditions, small intestine and colon, but unstable in the stomach caused by the enzymes.
出处
《安徽农业科学》
CAS
2013年第29期11640-11641,共2页
Journal of Anhui Agricultural Sciences
基金
河北农业大学青年科学基金(QJ201220)
