摘要
目的 :探讨肝纤维化血清标志物与肝活检病理变化之间的关系。方法 :对 82例慢性肝炎肝活检组织作HE染色及网状纤维嗜银染色 ,分别判断慢性肝炎炎症活动度及纤维化程度 ,同时检测患者血清HA、LN、Ⅳ .C、PCⅢ含量。结果 :血清HA、LN、PCⅢ含量均与慢性肝炎炎症活动度和纤维化程度呈正相关。LN、PCⅢ在肝纤维化早期即开始明显增高 ;HA从S2 期开始升高 ,但升高的幅度较大 ;Ⅳ .C在S3期才开始明显升高。HA、LN、PCⅢ在炎症早期即有升高 ;Ⅳ .C在G1-G3级都不升高 ,G4 级才有明显增高。结论 :检测慢性肝炎患者血清HA、LN、Ⅳ .C、PCⅢ含量可用于判断其病情严重程度 ,LN、PCⅢ能较早反映肝纤维化程度。
Objective:To study the relationship between the serum markers for liver fibrosis and the pathological changes in patients with chronic hepatits. Method:Biopsy was performed in 82 cases with chronic hepatitis and HE stain and reticular fibre argyrophil stain were done to determine the hepatits activity and fibrosis degree. The levels of HA,LN,Ⅳ,C and PCⅢ in serum from patients were deternined. Results:The levels of HA,LN and PCⅢ in serum were in positive correlation with the hepatitis activity and the fibrosis degree. LN and PCⅢ significantly increased in the early stage of the fibrosis;HA increased from the S 2 stage,with a greater raising scope;Ⅳ and C began to go up at S 3 stage. HA,LN and PCⅢ increased in the early stage of the inflammation;Ⅳ and c remained normal in grade G 1-G 3,began to raise in grade G 4. Conclusion:The determination of the levels of HA,LN,Ⅳ,c and PCⅢ in serum from patients with chronic hepatitis is helpful in the judgement of the severity of the disease. LN and PC can reflect the degree of the fibrosis in the earlier stage.
出处
《广州医学院学报》
2000年第4期16-19,共4页
Academic Journal of Guangzhou Medical College
关键词
肝纤维化
透明质酸
层粘蛋白
Ⅳ型胶原
Ⅲ型前胶原
慢性肝炎
liver fibrosis,pathological diagnosis,hyaluronic acid (A),Ln,type Ⅳ collagen,typeⅢ procollaten(PCⅢ).
