摘要
使用ESR波谱技术研究铝酞菁光化反应,以2,2,6.6-四甲基-4-羟基哌啶醇为探针,探测光化反应的中间产物及反应机制,结果表明,反应体系中氮氧自由基的生成依赖于氧的存在,D_2O的增进效应及β-胡萝卜素的抑制效应表明铝酞菁光化反应产生了单线态氧(~1O_2),SOD及细胞色素C的部分抑制效应表明光化反应中有少量超氧阴离子自由基(O_2)生成。
The photochemical reaction of sulfonated aluminum phthalocyanine (A1SPC) was studied by ESR spectrometry. By using TMHP as a probe, the intermediates of A1SPC photochemical reaction were detected according to the ESR signal of nitroxyl free radical. It was shown that the formation ofthe nitroxyl free radical——the photooxide of TMHP depends on the presence of oxygen. The results,that the ESR signal is enhanced by deuterated water(D2O), inhibited completely by β-carotene and partially inhibited by cytochrome C and superoxide dismutase(SOD), show that the singlet oxygen (1O2) is produced and is the main intermediate product.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1991年第2期227-230,共4页
Chemical Journal of Chinese Universities
关键词
光敏剂
铝
酞菁
学化反应
肿瘤治疗
Photosensitizer, Photochemical reaction, Inhibitor
