摘要
目的探讨2型糖尿病患者血清超敏C反应蛋白（hs-CRP）、白介素-6（IL．6）、肿瘤坏死因子-α（TNF-α）在糖尿病发生、发展过程中的浓度变化及与疾病并发肾病、糖化血红蛋白（HbAlc）程度、病程间相互关系。方法用双抗体夹心酶联免疫法和特种蛋白仪分析100例2型糖尿病患者及50例年龄和性别相匹配的正常对照者血浆CRP、IL-6、TNF-α和尿微量清蛋白（U-mALB）的水平。结果（1）2型糖尿病患者血中hs-CRP、IL．6和TNF-a的水平明显高于对照组（P〈O．01）；且糖尿痛肾病患者表现更明显。（2）2型糖尿病患者随着HbAlc的增高，血清中hs-CRP、IL．6和TNF-α也明显增高（P〈O．01）。（3）2型糖尿病患者血清中hs-CRP、IL-6和TNF-α随着病程的增加而表现增高趋势（P〈O．05）。（4）将糖尿病组血清中hs-CRP、IL-6和TNF-α与糖尿病病程、HbAlc及U—mALB进行直线回归相关分析，表现出低度的相关性（P〈0．0S）。结论炎性因子hs-CRP、IL-6及TNF-α在糖尿病的发生、发展过程中相互作用，观察其浓度变化对探讨糖尿病的发病机理、预防及指导用药均有重要价值。
Objective To investigate the role played by serum relative inflammatory cytokine （hs-CRP, IL-6, TNF-α）in the path- ogenesis of diabetes mellitus. Methods Serum hs-CRP,IL-6,TNF-α and U-mALB leves were measured with ELISA and biochemis- try analysis system for special proteins in 33 cases diabetic patients without complications,67 cases patients with early nephro or retinopathy and 50 eases controls. Results ①erum leves of hs-CRP, IL-6 and TNF-α were significantly higher in the diabetic pa- tients than those in controls （P〈0.01）. ②The serum leves of these relative inflammatory cytokine factors were mutually positively correlated with HbAlc（P〈0.01）. ③The serum leves of these relative inflammatory cytokine factors were positively correlated with disease course（P〈0.05）. Conclusion The relative inflammatory cytokine factors hs-CRP,IL-6 and TNF-α participated in the development and pathophysiology of diabetes mellitus and monitoring their plasma level changes would be clinically useful.
出处
《国际检验医学杂志》
CAS
2013年第B12期7-9,共3页
International Journal of Laboratory Medicine
关键词
炎性因子
C反应蛋白
白介素-6
肿瘤坏死因子
2型糖尿病
Inflammatory cytokine
C reactive protein
interleukin-6
tumor necrosis factor type 2 diabetes mellitus
