摘要
目的对比观察齐拉西酮和奥氮平治疗精神分裂症的临床疗效。方法 78例精神分裂症患者被随机分为两组,分别给予齐拉西酮和奥氮平口服治疗,比较两组患者的治疗疗效及不良反应(TESS量表),并于治疗前,治疗后1、2、4、8周记录PANSS评分比较。结果两组治疗结束时PANSS评分较治疗前明显降低(P<0.05);治疗开始后,齐拉西酮组各时间点PA N SS减分率于奥氮平组无明显差异(P>0.0 5);两组不良反应发生率无明显差异(P>0.0 5),但奥氮平组以体重增加为主,齐拉西酮组以心动过速,失眠,恶心为主,两组间差异具有统计学意义(P<0.05);奥氮平治疗的有效率为79.5%,齐拉西酮治疗的有效率为84.6%,两组间无明显差异(P>0.05)。结论奥氮平和齐拉西酮均能有效治疗精神分裂症,两种药物的主要不良反应不同,可根据患者情况具体选择相应药物。
Objective To investigate tne eiiect ul e r Methods 78 patients with schizophrenia were divided into two groups randomly.one group was treated with olanzapine, and the other group was employed with ziprasidone. The effects and adverse reactions were compared in two groups. Results The score of PANSS in both groups decreased significantly comparing to the baseline, the rate of arrhythmia, insomnia and insomnia were significantly higher in the ziprasidone group than those in the olanzapine group（P〈0.05）, patients in olanzapine group has more significant effect on body weight than ziprasidone（P〈0-05）-T^tal clinical effective rates were 79.5%in olanzapine groups and 84.6%irt zipresidone, without any significant difference between the two groups. Conlusioll Both antipsychotics are good choice for treatment of schizophrenia, the differences in adverse reactions will help doctors make individual treatment decision accordingly.
出处
《中国卫生产业》
2013年第32期136-137,共2页
China Health Industry
