摘要
目的：探讨糖尿病高危孕妇妊娠晚期血糖再筛查的临床价值.方法：选取妊娠24～28周50 g葡萄糖筛查试验（glucose challenge test,GCT）阴性但有糖尿病高危因素的孕妇600例,于妊娠32～34周再行50 g GCT筛查,阳性者再作100 g口服葡萄糖耐量试验（oral glucose tolerance test,OGTT）.根据检查结果,将600例孕妇分为4组,并对这4组孕妇及围产儿结局进行比较.结果：首次GCT阴性的600例孕妇中,妊娠期糖尿病（gestational diabetes mellitus,GDM）和妊娠期糖耐量受损（gestational impaired glucose tolerance,GIGT）的患病率分别为2.3％和5.2％.GDM组的年龄、分娩前体质量指数、合并羊水过多者、巨大儿发生率与GCT（-）组差异有统计学意义.GDM组、GIGT组及GCT（＋）组孕妇的孕前体质量、妊娠高血压发生率、手术分娩率、新生儿病率的差异有统计学意义.结论：妊娠期糖代谢异常能增加孕产期并发症和围产儿的患病率.因此,对首次GCT阴性者在妊娠晚期再次血糖筛查与管理是非常必要的.
Objective：To evaluate the clinical value of glucose screening retest in high-risk pregnant women of gestational diabetes mellitus （GDM） in late pregnancy.Methods：A total of 600 cases of pregnant women with 50 g glucose challenge test （GCT） negative in 24-28 weeks,but had risk factors of diabetes mellitus.And 600 pregnant women retseted 50 g GCT in 32-34 weeks,meanwhile who with 50g GCT positive took 100 g oral glucose tolerance test.According to the inspection results,600 pregnant women were divided into 4 groups.And pregnant women and perinatal outcomes of 4 groups were compared.Results：In 600 cases of pregnant women with the first time GCT negative,the incidence rates of GDM and gestational impaired glucose tolerance（GIGT） were 2.3％ and 5.2％,respectively.The age,body mass index before delivery,polyhydramnios,incidence of macrosomia of GDM group were obviously higher than those of GCT （-） group.maternal pre-pregnancy weight,pregnancy induced hypertension disease incidence,operation delivery rate,neonatal disease rate of GDM group,GIGT group,and GCT （＋） group were significantly different.Conclusions：Gestational abnormal glucose metabolism can increase the maternal complications and neonatal disease rate.Further understanding of risk factors of GDMis necessary,and it is necessary for the pregnant women with the first time GCT negative to retest blood glucose screening and management.
出处
《中国临床医学》
2013年第5期684-686,共3页
Chinese Journal of Clinical Medicine
基金
上海市卫生局课题(编号:2008003)
关键词
妊娠期糖尿病
葡萄糖筛查试验
高危因素
Gestational diabetes mellitus
Gluase challenge test
High risk factors
