摘要
长链非编码RNA(long non-coding RNA,lncRNA)是一类转录本长度大于200 bp的非编码RNA,可作为人类基因组中一类重要的调控分子通过多种方式发挥其生物学功能.近年来的研究表明,lncRNA也可以作为一种竞争性内源性RNA(competing endogenous RNA,ceRNA)与miRNA相互作用,参与靶基因的表达调控,并在肿瘤的发生发展中发挥重要的作用.本综述在简要介绍lncRNA功能研究现状和主要研究方法的基础上,进一步分析了lncRNA与miRNA之间的互相调控关系及其在肿瘤发生发展中的作用,以便为后续的研究提供新的思路.
Long non-coding RNA（lncRNA） is a kind of non-coding RNA, and their transcripts are more than 200 bp in length, lncRNA plays important roles as a regulatory molecule by a variety of mechanisms. Recent studies show that lncRNA can interact with the miRNA as a competing endogenous RNA （ceRNA） to participate in the expression regulation of target genes, which exert an important role in the initiation and progression of tumor. In this review, based on a brief introduction to the function of lncRNA and major research methods, we expect to provide a reference for the further study of the regulatory relationship between the interaction of lncRNA and miRNA and its role in the initiation and progression of tumor.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2013年第11期1029-1034,共6页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.81272297)资助~~
