摘要
目的探讨前列腺基底细胞增生和基底细胞癌的组织形态学特征,提高前列腺病变的诊断与鉴别诊断水平。方法回顾性分析10例前列腺基底细胞增生和1例前列腺基底细胞癌病例特征,观察其形态学特征,并做基底细胞特异性标记高分子角蛋白抗体(34βΕ12)、P63蛋白及前列腺特异性抗原(PSA)免疫组织化学染色。结果基底细胞增生镜下表现为基底细胞密度增加,层次增多,可环绕腺腔增生多层,或在腺泡一侧呈小灶状、片状增生,增生也可呈实性巢或筛状结构,几种形态常混合存在。增生的基底细胞无异型性及核分裂像,核仁不易见。基底细胞癌镜下呈不规则实性团片状,在纤维结缔组织中呈浸润性生长,细胞核染色深,细胞核浆比大,异型性明显,核分裂像易见。结论基底细胞增生镜下形态多样,与基底细胞癌鉴别主要依赖组织形态学特征,免疫组织化学可以辅助鉴别诊断。
Objective To recognize the morphologic features of prostatic basal cell hyperplasia（BCH）and basal cell carcinoma in order to facilitate the diagnosis and differential diagnosis of prostate lesions. Methods 10 cases of BCH and a case of basal cell carcinoma of the prostate were reviewed;their morpho-logic varieties were carefully observed and immunoperoxidase stains for basal cell specific antibody 34βE12,P63 and PSA were also performed.Results The morphology of prostatic BCH are shown by the increased density,forming double layer-glandlike,or layers,solid,or cribriform often with admixed growth patterns.The hyperplasia basal cells have not atypia and mitotic figures,nucleoli.Basal cell carci-noma consisted of solid sheets and nests,and infiltrated to fiber tissues,which had large nucleoli,mitoses were frequently seen.Conclusion The microscopic features of BCH are of varieties,which should be dif-ferentiated with basal cell carcinoma.The diagnosis of BCH mainly relies on its specific morphologic fea-tures,and immunoperoxidase stains is helpful in diagnosis and differential diagnosis.
出处
《新疆医科大学学报》
CAS
2013年第10期1434-1436,1441,共4页
Journal of Xinjiang Medical University
基金
卫生部医药卫生科技发展研究中心课题(W2012GJ28)
