摘要
目的探讨黄芪注射液对I～II期圧疮患者的治疗效果及其机制。方法将56例I～II期圧疮患者随机分为对照组(n=28)和实验组(n=28),实验组给予黄芪注射液均匀涂于患处,对照组采取1%甲紫外涂,比较两组临床疗效及愈合时间,并行ELISA检测治疗前后血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平。结果实验组总有效率及愈合时间明显高于对照组(P<0.05)。治疗前,两组血清IL-1β、IL-6水平比较,差异均无显著性(P>0.05),治疗后,实验组血清IL-1β、IL-6水平显著低于对照组(P>0.05)。结论黄芪注射液治疗I～II期圧疮疗效较好,其机制可能与抑制炎性反应有关。
Objective To explore the influence of Astragalus injection on curative effect in pressure ulcer patients with I to II stages and its mechanism. Methods Fifty-six pressure ulcer patients with I to II stages were randomly divided into control group （n=28） and experimental group （n=28）. Patients in experimental group were treated with Astragalus injection; however, those in control group received 1% methylrosanilinium chloride. The clinical curative effect and healing time were compared between both groups. Moreover, serum levels of interleukin-1β （IL-1β） and interleukin-6 （IL-6） were detected by ELISA before and aider treatment. Results The total effective rate and healing time in experimental group were significantly higher than levels between experimental group and control group （P〉0.05） before treatment. After treatment, serum IL-1β and IL-6 levels were decreased in experimental group compared with control group （P〈0.05）. Conclusion Astragalus injection produces better protection against pressure ulcer with I to II stages. The mechanisms are associated with inhibition of inflammatory reaction.
出处
《中国医药指南》
2013年第29期2-2,24,共2页
Guide of China Medicine
基金
湖南省科技厅科技计划项目(NO:2011SK3026)
