摘要
目的:探讨依达拉奉对脑出血患者血清IL-6、CRP的影响,研究依达拉奉对出血性脑损伤的保护机制;方法:选择70例脑出血患者随机分为依达拉奉组和对照组,1d、7d、14d、21d进行神经功能评分并检测患者血清IL-6、CRP水平;结果:两组7d、14d、21d较治疗前神经功能缺损有明显改善(P<0.01),治疗后14d、21d与对照组比较神经功能缺损评分有统计学意义(P<0.05);依达拉奉组与对照组比较,7d、14d、21d时血清IL-6、CRP水平下降(P<0.05);结论:依达拉奉明显降低血清IL-6、CRP水平,从而减轻出血性脑损伤,对受损脑组织发挥保护作用。
Objective ： To investigate the effect of Edaravone on IL - 6 and CRP in serum from cerebral hemor- rhage patients; and study the protection mechanism of Edaravone in hemorrhagic brain damage; Methods ：70 cere- bral hemorrhage patients were randomly divided into edaravone group and control group. IL -6 and CRP in patients serum were tested and the Neurological Scores were taken at ld, 7d, 14d and 21d treatment. Results： The Neu- rological Deficit at 7d, 14d and 21d had better improvement than before in both groups（ P 〈0.01 ）. At 14d and 21d, the Neurological Deficit Scores of Edaravone group and the control group showed statistical significance after treatment （ P 〈 0.05） ; Compared with the control group, IL - 6 and CRP in serum in Edaravone at 7d, 14d and 21d were significantly lower （P 〈 0.05 ） ; Conclusion： Edaravone markedly decreased the level of IL- 6 and CRP in serum, and alleviated hemorrhagic brain injury, thus protecting the damaged brain tissue.
出处
《湖北职业技术学院学报》
2013年第3期110-112,52,共4页
Journal of Hubei Polytechnic Institute
