摘要
随着对端粒和端粒酶在衰老和肿瘤中重要性认识的不断深入 ,端粒酶的激活途径已日益成为这一研究领域的热点 .已发现 ,MYC原癌蛋白 (myelocytomatosisvirusoncoprotein ,MYC)在端粒酶的激活中起关键作用 .它可以与TERT基因启动子区域内的E盒结合反式直接激活端粒酶 ,还可能介导了细胞内其他分子如人乳头瘤病毒E6癌蛋白 (humanpapillomavirusE6oncoprotein ,HPV E6 )和雌激素等对端粒酶的激活 .雌激素也可与雌激素受体形成复合物 ,直接与TERT基因启动子区域内的退化雌激素反应元件结合反式激活端粒酶 .此外 ,腺瘤样结肠息肉癌蛋白 (adenomatouspolyposiscoliprotein ,APC)、p5
Following the importances of telomere and telomerase in senescence and tumor were recognized, the pathway of telomerase activation is becoming the focus of this area. By now, MYC was found to play key role in telomerase activation. It could activate telomerase directly by binding to E box in promoter region of TERT gene. At the same time, MYC might mediate other molecules to activate telomerase, such as HPV E6 and estrogen. Estrogen could activate telomerase directly by forming estrogen/estrogen receptor complex binding to imperfect palindromic degenerate estrogen responding element in promoter region of TERT gene. APC, p53 and protein phosphorylation might also involve in telomerase activation.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2000年第6期602-605,共4页
Progress In Biochemistry and Biophysics
