摘要
目的探讨新诊断酮症起病超重或肥胖糖尿病患者的临床特征和初步分型。方法根据体质指数（BMI）将86例新诊断酮症起病糖尿病患者分为三组：低体重组（A组，BMI≤18．5kg／m^2，16例）、正常体重组（B组，BMI为18．6～23．9kg／m^2，45例）及超重或肥胖组（C组，BMI≥24．0kg／m^2，25例）。52例非酮症起病超重或肥胖2型糖尿病患者为D组。分别比较A组、B组和C组的临床资料及C组和D组的临床资料。结果①C组及B组的发病年龄明显高于A组（均P〈0．01），谷氨酸脱羧酶抗体/蛋白酪氨酸磷酸酶抗体阳性率、随机血糖及血隘丁酸水平均明显低于A组（P〈0．01或P〈0．05）。C组伴代谢综合征比例、二氧化碳结合力、空腹C肽及餐后2hC肽水平均明显高于A组及B组（P〈0．01或P〈0．05），血压及餐后C肽增加值水平明显高于A组（P〈0．01或P〈0．05）。②C组随机血糖及糖化血红蛋白水平明显高于D组（均P〈0．01），空腹C肽、餐后2hC肽及餐后C肽增加值水平均明显低于D组（均P〈0．01）。两组在发病年龄、病程、糖尿病家族史、伴代谢综合征比例、BMI、腰围、体重下降程度、血压、血脂水平间的比较差异均无统计学意义（均P〉0．05）。结论新诊断酮症起病超重或肥胖糖尿病患者更倾向于2型糖尿病。
Objective To investigate the clinical characteristics and primary classification of overweight or obese patients with newly diagnosed ketosis-onset diabetes. Methods According to body mass index （BMI）, 86 pa- tients with newly diagnosed ketosis-onset diabetes were divided into three groups： underweight group （group A, BMI≤18.5 kg/m^2, n=16）, normal body weight group （group B, BMI 18.6-23.9 kg/m^2, n=45）, overweight or obese group （group C, BMI≥24.0 kg/m^2, n=25）. Fifty-two overweight or obese type 2 diabetes patients without ketosis were selected as control （group D）. Clinical characteristics were compared among group A, group B and group C, as well as between group C and group D. Results （1） Compared with group A, age in group C and group B was significantly old- er （both P〈0.01）, the positive rate of glutamic acid decarboxylase antibody/protein tyrosine phosphate antibody and the levels of random blood glucose and β hydroxybutyric acid in group C and group B were significantly lower （P〈0.01 or P〈0.05）. Group C had obviously higher levels in presence of metabolic syndrome, carbon dioxide combining power, fast- ing C-peptide and postprandial C-peptide than those in group A and group B （P〈0.01 or P〈0.05）. The levels of blood pres- sure and A C-peptide in group C were significantly higher than those in group A （P〈0.01 or P〈0.05）. （2） Compared with group D, group C had significantly higher levels in random blood glucose and glycosylated hemoglobin （both P〈0.01）, and significantly lower levels in fasting C-peptide, postprandial C-peptide and △ C-peptide （all P〈0.01）. There was no significant differences regarding some clinical features, such as age, course of disease, family history, presence of meta- bolic syndrome, BMI, waist circumference, weight loss, blood pressure and blood lipid （all P〉0.05）. Conclusion Over- weight or obese patients with newly diagnosed ketosis-onset diabetes are more likely to be classified as type 2 diabetes.
出处
《海南医学》
CAS
2013年第17期2504-2507,共4页
Hainan Medical Journal
基金
贵州省优秀科技教育人才省长专项资金项目(编号:200760)
贵州省社会发展攻关项目(编号:SY20083051)
高层次人才科研条件特助经费项目(编号:TZJF200747)
关键词
糖尿病
酮症
肥胖
分型
Diabetes meltitus
Ketosis
Obesity
Classification
