摘要
目的探讨高体质量指数(BMI)对多囊卵巢综合征(PCOS)患者行体外受精-胚胎移植(IVF-ET)的妊娠结局的影响。方法回顾性分析2009年1月至2011年12月于郑州大学第三附属医院生殖中心用标准长方案进行IVF助孕的224例PCOS患者资料,根据BMI分为2组,高BMI组(BMI≥24.0)60例,正常BMI组(18.5≤BMI<24.0)164例,分析高BMI与正常BMI的PCOS患者妊娠结局的差异。结果 (1)高BMI组基础睾酮(T)显著高于正常BMI组(P<0.05);(2)两组促性腺激素(Gn)总量、Gn用药、促排天数、获卵数、受精卵数目差异无统计学意义(P>0.05),但高BMI组子宫内膜厚度显著高于于正常BMI组,差异有统计学意义(P<0.05);(3)两组临床妊娠率、胚胎种植率、流产率、平均孕周、胎儿平均体质量差异无统计学意义(P>0.05),高BMI组妊娠期糖尿病(GDM)显著高于正常BMI组,差异有统计学意义(P<0.05)。结论高BMI的PCOS患者易出现高雄激素血症,且妊娠期并发症GDM发生率增加,但不影响其临床妊娠率。
Objective To investigate the influence of high body mass index （BMI） on in vitro fertilization and embryo transfer （IVF-ET） pregnancy outcome in the patients with polycystic ovary syndrome （PCOS） .Methods A retrospective cohort study was conducted using existing data on 224 PCOS patients with IVF-ET by the standard long protocol in this hospital from Jan 2009 to Dec 2011 .All patients were divided into 2 groups according to BMI ,the high BMI group（BMI≥24 .0 ,64 cases） and the normal BMI group（18 .5≤BMI〈24 .0 ,160 cases） .The differences of pregnaney outcomes between the high BMI and normal BMI PCOS pa-tients were compared .Results 1 .Basic testosterone（T） in the high BMI group was higher than that in the normal BMI group（P〈0 .05） .2 .There were no statistical difference in the number of retrived oocytes ,dose of Gn ,Gn duration ,fertilization rate between the two groups（P〉0 .05）;the high BMI group demonstrated the higher endometrial thickness and lower good quality embryo rate than the normal BMI group（P〈0 .05） .3 .There were no statistical difference in the clinical pregnancy rate and the abortion rate be-tween the two groups（P〉0 .05） ,the high BMI group had the higher risk of developing gestational diabetes（GDM）than the normal BMI group（P〈0 .05） .Conclusion PCOS patient with high BMI is liable to develop hyperandrogenism and increases the occurrence rate of pregnancy complication gestational diabetes mellitus （GDM ） ,but without affecting the clinical pregnancy rate .
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第27期3246-3248,共3页
Chongqing medicine
基金
河南省科技攻关项目(2011020054)
