摘要
目的研究血清Cys C(Cys C)、尿微量清蛋白(UmAlb)对糖尿病肾病(DN)早期患者临床诊断价值,并根据2种标志物的特点和患者的病情选择合适的检测方法。方法将75例糖尿病早期患者分为A组(25例,1型糖尿病)和B组(25例,2型糖尿病),同时选取健康对照(C组)25例。同时测定Cys C、UmAlb、糖化血红蛋白(HbA1c),单因素方差分析各组间指标的差异,进一步通过一元线性回归讨论Cys C与HbA1c之间的关系。结果A、B两组患者的Cys C、UmAlb水平普遍高于C组,差异有统计学意义(P<0.05);Cys C在A、B两组间差异有统计学意义(P<0.05);而UmAlb在A、B两组患者间差异无统计学意义(P>0.05)。结论 Cys C的测定对糖尿病肾病早期诊断优于UmAlb,且与患者病情发展呈正相关性;应根据两种标志物的特点和患者的病情选择合适的检测方法。定期检查糖尿病患者血清Cys C水平,可指导临床治疗,评估患者预后。
Objective To investigate clinical diagnostic value of serum cystatin C（Cys C）,urinary microalbumin（UmAlb）for early diabetic nephropathy（DN）.Methods 50cases of early diabetic patients were divided into group A（25cases with type 1diabetes）and group B（25cases with type 2diabetes）,and 25healthy subjects were enroll as group C.Cys C,UmAlb and glycated hemoglobin A1c（HbA1c）were detected and the differences between groups were analyzed by ANOVA test.Then the relationship between Cys C and HbA1cwere analyzed by linear regression and correlation analysis.Results Levels of Cys C and UmAlb in group A and B were higher than group C significantly（P0.05）.There was significant difference of Cys C level between group A and B（P0.05）.While there was no significant difference of UmAlb level between group A and B（P0.05）.Conclusion Determination of Cys C might be better than UmAlb in the early diagnosis of ND,and could be positively correlated with disease progression..Appropriate detection should be selected in clinical work,according to the characteristics of the markers and the patient′s disease condition.Furthermore,serum Cys C monitoring could guide clinical treatment and assess disease prognosis.
出处
《检验医学与临床》
CAS
2013年第18期2383-2384,共2页
Laboratory Medicine and Clinic
