摘要
目的探讨开心散对失眠模型大鼠睡眠周期的影响。方法采用间断电流刺激法建立失眠大鼠模型。将48只大鼠随机分为6组,每组8只,分别为空白对照组,失眠对照组,地西泮(4 mg·kg-1)对照组,开心散低、中、高剂量组(2,4,8 g·kg-1),连续灌胃7 d后,通过皮层脑电描计方法,观察开心散对失眠大鼠睡眠周期的影响。结果失眠对照组觉醒时间(277.6±19.3)min,总睡眠时间(202.4±23.5)min;开心散中、高剂量组大鼠觉醒时间分别为(229.6±11.5),(211.4±13.1)min,睡眠总时间分别为(250.4±32.6),(268.6±29.7)min,且以慢波睡眠Ⅱ期(SWS2)和快动眼睡眠(REMS)的延长更显著(P<0.05),其作用优于地西泮对照组。结论开心散具有显著的促睡眠效应,主要通过延长SWS2和REMS期来实现。
Objective To study the effect of kaixin powder on the sleep cycle of insomnic rats. Methods The insomnic rat model was established with a intermittent current stimulation. The rats were randomly divided into six groups, the negative control, insomniac control, diazepam control （4 mg · kg-1） , low, middle, high doses of kaixin （2,4,8 g · kg -1 ） powder groups. The mice were orally administered with the drugs or vehicle for seven consecutive days, and the effect of kaixin powder on the sleep cycle of insomnic mice was studied with electrocorticography. Results The wake time in the mid and high dose groups were （229.6± 11.5 ） and （211.4± 13.1 ） min, respectively, which was improved compared with the negative control group （277.6±19.3） min. The total sleep time （TST） in the mid [ （250.4±32.6） rain] and high [ （268.6±29.7） rain ] dose groups were also improved from the negative control group [ （202.4±23.5） mini. The improvement effects of kaixin powder were especially obvious for the SWS2 and REMS, which were superior to the diazepam positive control. Conclusion Kaixin powder can improve sleep of insomnic rats by extending SWS2 and REMS.
出处
《医药导报》
CAS
北大核心
2013年第9期1124-1126,共3页
Herald of Medicine
关键词
开心散
失眠模型
睡眠周期
Kaixin powder
Insomnic model
Sleep cycle
