摘要
目的探讨血清癌抗原125（CAl25）值的动态变化对上皮性卵巢癌（EOC）患者治疗效果及预后判断中的应用价值。方法回顾性分析84例EOC患者的临床资料，探讨治疗前后CAl25的变化、CAl25半衰期及其转阴时间与患者存活时间及复发的关系。结果经手术治疗患者血清CAl25水平显著低于治疗前（t=11．306，P〈0．01），术后经6个周期的规范化疗之后，血清CAl25再次呈显著性降低（t=6．265，P〈0．01）；CAl25半衰期（Tl／2）≤20d组存活时间显著长于T，／2〉20d组（t=3．394，P〈0．01）；与CAl25转阴时间（NT）〉8周者相比，NT≤8周患者存活时间显著较长（t=2．791，P〈0．01），复发率显著降低（22．9％与58．3％）（X。=10．941，P〈0．01），复发时间显著较晚（t=15．965，P〈0．01）。结论CAl25值动态变化在EOC患者的疗效判断及预后评估方面具有重要临床应用价值，CAl25半衰期较短、转阴较快的EOC患者治疗效果更好，生存期更长，术后复发率更低。
Objective To explore the clinical value of the dynamic change of serum carbohydrate antigen 125 （CA125） in the evaluation of the therapeutic effect and prognosis in patients with epithelial ovarian cancer （EOC）. Methods The clinical data of 84 patients with EOC were retrospectively analyzed. The change of before and after treatment ,the half-life of CA125 ,the relationship between the clearance time of CA125 and the survival time and recurrence of patients were investigated. Results After operation, the serum level of CA125 was significantly lower than that before treatment（ t = 11. 306 ,P 〈 0.01 ）. After 6 cycles of standard chemotherapy, the serum CA125 again decreased evidently（ t = 6. 265 ,P 〈 0.01 ）. In the half-life of CA125 （T1/2 ） ≤ 20d group ,the survival time was signifi- cantly longer than TI/2 〉 20d group（ t = 3. 394 ,P 〈 0.01 ）. Compared with CA125 negative conversion time（NT） 〉 8 weeks group ,the survival time of NT ≤8 weeks was significantly longer （t = 2. 791, P 〈 0.01 ） , the recurrence rate was significantly lower（ 22.9% vs. 58.3% ） （ X2 = 10.941 ,P 〈 0.01 ）, the recurrence time was later（ t = 15. 965, P 〈 0.01 ）. Conclusion The dynamic change of CA125 has important clinical value in the evaluation of the therapeutic effect and prognosis of patients with EOC. EOC patients with short CA125 half-life, faster negative conversion time have better treatment effect,longer survival,lower recurrence rate after operation.
出处
《中国基层医药》
CAS
2013年第22期3381-3383,共3页
Chinese Journal of Primary Medicine and Pharmacy
关键词
癌胚抗原
卵巢肿瘤
疗效
诊断
Careinoembryonic antigen
Ovarian neoplasms
Effects
Diagnosis
