摘要
目的 初步探讨肾病综合征时低蛋白高脂血症的发生与大量蛋白尿之间的关系。方法 观察双肾用阿霉素大量蛋白尿（Ａ）组与经典肾病模型（Ｂ） 组大鼠血浆蛋白与血脂水平的变化。结果 ２ 组在尿蛋白排泄量类似的情况下，Ａ组血白蛋白不如Ｂ组下降明显（ Ｐ＜０ ．０１） ，血总胆固醇、三酰甘油（ 又称甘油三酯） 不如Ｂ组升高显著（ Ｐ＜ ０．０１）。结论 大量蛋白尿不是阿霉素肾病低蛋白高脂血症发生的惟一因素。
Objective To further study the effect of massive proteinuria on nephrotic hypoalbuminemia and hyperlipidemia in rats. Methods The changes were observed of serum albumin, cholesterol and triacylglycerol concentrations in rats of group A (perfused with 45 mg of adriamycin per kilogram of kidney weight via bilateral renal arteries), and of group B (perfused with 6.5 mg of adriamycin per kilogram of body weight via the tail vein). Results No significant difference in the level of urine protein was found between groups A and B [(425.3±11.87) mg/d vs (441.93±16.83) mg/d, P>0.05]. Serum albumin concentration in group A was higher than in group B [(25 00±1.56) g/L vs (14.03±2.71) g/L,P<0.01], serum cholesterol in group A was lower than in group B [(2.67±0.89) mmol/L vs (6.16±0.71) mmol/L, P<0.01],and serum triglyceride in group A was lower than in group B [(0.80±0.55) mmol/L vs (5.0±3 29) mmol/L,P<0.01]. Conclusion The massive proteinuria may not be the sole cause of hypoalbuminemia and hyperlipidemia in rats with nephrotic syndrome induced by adriamycin.
出处
《徐州医学院学报》
CAS
2000年第1期28-30,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省自然科学基金!资助项目(BK97155)。
关键词
肾病综合征
蛋白尿
低蛋白血症
高脂血症
nephrotic syndrome
proteinuria
hypoalbuminemia
hyperlipidemia
