摘要
目的：探讨在常规连续放疗中，总治疗时间延长及疗程中断长短对鼻咽癌局部控制和远期生存的影响。方法：选择 1989年 1月～ 1992年 12月在我科住院接受单纯常规连续放疗、经病理证实的Ⅰ～Ⅳ a期鼻咽癌病人 196例进行回顾性分析，以中位总疗程时间及疗程中断时间为界分别分为疗程≤ 50天和 >50天两组及疗程中断≤ 5天和 >5天两组，采用 Kaplan Meier和 Log rank法对局控、无瘤生存和无远处转移率进行分组比较，时间因素与局控率关系采用线性回归分析，多因素分析采用 Cox模型法。结果：在未限定总剂量范围之前，不同疗程组或疗程中断组之间的 5年局控率无显著差异。当选择鼻咽剂量在 66～ 70 Gy范围的 115例病人进行分析时，疗程 >50天和中断 >5天组的 5年局控率（分别为 44.0％和 38.9％）、无瘤生存率（ 39.8％和 33.5％）和无远处转移率（ 48.5％和 42.6％）均明显低于疗程≤ 50天和中断≤ 5天组（相应为 63.4％和 63.1％、 63.5％和 63.2％、 68.7％和 68.9％），
Objective: To study the influence of prolonged overall treatment time (OTT) and treatment interruptions (TI) on local control and survival in conventional continuous radiotherapy for nasopharyngeal carcinoma. Methods: From January 1989 to December 1992, 196 hospitalized patients diagnosed with stageⅠ～Ⅳ nasopharyngeal carcinoma and received conventional continuous radiotherapy alone were selected to analyze retrospectively. All patients were respectively divided into OTT≤ 50 days and >50 days two groups and TI≤ 5 days and >5 days two groups in term of the media value of OTT and TI. The effect of OTT and TI on free from regional failure (FRF), disease free survival (DFS) and distant metastases free (DMF) were evaluated using Kaplan Meier and Log rank. The relationship between time factor and local control was analyzed using Linear regression. Cox model was performed for multivariate analyses. Results: No significance was noted on 5 year local control rate between two OTT groups or two TI groups before the range of total dose was not confined. When 115 patients who received a total dose of 66～ 70 Gy in the nasopharynx were selected for analyses, the 5 year FRF, DFS and DMF rates in OTT >50 days (44.0％ , 39.8％ and 48.5％ , respectively) and TI >5 days (38.9％ , 33.5％ and 42.6％ , respectively) were significantly lower than those in OTT≤ 50 days (63.4％ , 63.5％ and 68.7％ , respectively) and TI≤ 5 days (63.1％ , 63.2％ and 68.9％ , respectively.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第10期923-926,共4页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
总治疗时间
治疗中断
放射治疗
Nasopharyngeal neoplasms
Radiotherapy
Overall treatment time
Treatment interruptions
