摘要
背景:目前研究腰椎间盘退变的磁共振分子影像主要有T2mapping和T1ρ两种技术。目的:探讨1.5TMR用于新西兰大白兔腰椎间盘T2mapping成像的可行性。方法:采用1.5TMR设备进行新西兰大白兔腰椎间盘磁共振T2mapping成像,利用后处理工作站测量感兴趣区的腰椎间盘组织T2值。结果与结论:在1.5TMR设备上可获得满意的3月龄新西兰大白兔腰椎间盘矢状位与冠状位T2-map图像。PfirrmannⅠ级的L_(4/5)、L_(5/6)及L_(6/7)椎间盘中央部髓核组织T2值分别为(104.6±14.0)ms,(109.1±13.8)ms和(109.5±15.1)ms;腹侧纤维环T2值分别为(82.1±9.5)ms,(80.4±11.2)ms和(79.9±10.6)ms;背侧纤维环T2值分别为(85.8±11.9)ms,(85.1±12.1)ms和(85.3±9.3)ms。在PfirrmannⅠ级的L_(4/5)、L_(5/6)及L_(6/7)三组间椎间盘髓核组织、腹侧纤维环和背侧纤维环的T2值差异均无显著性意义(P>0.05)。然而同一椎间盘内髓核组织T2值高于纤维环T2值(P<0.01),而腹侧与背侧纤维环之间的T2值差异无显著性意义(P>0.05)。可见在1.5TMR设备上获得的兔腰椎间盘T2值可用于定量评估椎间盘组织信号。
BACKGROUND： The magnetic resonance molecular imaging used in the research of lumbar disc degeneration includes T2 mapping and Tlp technologies at present. OBJECTIVE： To evaluate the feasibility of 1.5 T MR equipment on T2 mapping of New Zealand white rabbits lumbar disc. METHODS： T2 mapping images of New Zealand white rabbit lumbar discs were obtained on 1.5 T MR equipment. The regions of interest T2 values of lumbar discs were measured with post-processing workstation. RESULTS AND CONCLUSION： Sagittal and coronal T2 maps of 3-month rabbit discs were obtained satisfactorily on 1.5 T MR equipment. The regions of interest T2 values of nucleus pulposus in L4/5, L5/6 and L6/7 discs were （104.6±14.0） ms, （109.1±13.8） ms and （109.5±15.1 ） ms respectively at Pfirrmann I grade. The regions of interest T2 values of anterior annulus fibrosus in L4/5, L5/6 and L6/7 discs were （82.1±9.5） ms, （80.4± 11.2） ms and （79.9±10.6） ms respectively, and T2 values of posterior annulus fibrosus in L4/5, L5/6 and L6n discs were （85.8±11.9） ms, （85.1±12.1） ms and （85.3：1：9.3） ms respectively. There were no significant differences in T2 values of nucleus pulposus, anterior annulus fibrosus and posterior annulus fibrosus in L4/5, L/6 and L6/7 discs at Pfirrmann I grade （P 〉 0.05）. However, the T2 values of nucleus pulposus were higher than those of annulus fibrosus in the same discs （P 〈 0.01）, and there were no significant differences in T2 values between the anterior and posterior annulus fibrosus （P 〉 0.05）. The T2 values of rabbit lumbar discs obtained on 1.5 T MR equipmentcan be used for quantitative assessment of intervertebral disc signal.
出处
《中国组织工程研究》
CAS
CSCD
2013年第35期6281-6286,共6页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金资助项目(81272041)
广东省自然科学基金资助项目(10151008901000202)~~
关键词
骨关节植入物
骨与关节图像和影像
脊柱损伤基础实验
椎间盘退变
动物模型
髓核
磁共振成像
磁共振分子影像
T2
MAPPING
兔
国家自然科学基金
bone and joint implants
images and video of bone and joint
basic experiment of spinal cord injury
discdegeneration
animal model
nucleus pulposus
magnetic resonance imaging
magnetic resonance molecular imaging
T2 mapping
rabbit
National Natural Science Foundation of China
