摘要
目的 :为了阻止或减少口腔细菌在屏障膜放置期间定植于膜上 ,研制了一种抗生素的缓释给药系统 (SRDDS) ,并评价SRDDS在体内外的药物释放持续时间和相应浓度。方法 :在体外 ,6个单位的SRDDS被分别置于PBS中 ,通过紫外分光光度法测定每日药物溶出量。在体内 ,在 6只兔子的人工颅骨缺损中分别植入SRDDS ,并通过抗生素微生物检定法测定骨缺损附近的药物浓度。结果 :在体外 ,药物能持续稳定地从SRDDS中释放出来 ;至第 2 8天 ,共有约 6 3%的药物被释放。在体内 ,2 5mg/L以上的药物浓度至少能维持 6周。结论
AIM: To prevent or at least to reduce the bacterial colonization on barrier membranes during the period of membrane retention, a local sustained-release drug delivery system (SRDDS) for antibiotic was developed. The drug release behavior of such a SRDDS in vitro and in vivo was evaluated in this study. METHODS: In vitro , 6 units of SRDDS were respectively placed into PBS and the amount of daily drug release were measured by UV-spectrophotometry. In vivo , 6 units of SRDDS were respectively implanted into parietal bone defects of 6 rabbits. The concentration of drug adjacent to the defects was measured by a bioassay technique. RESULTS: In vitro , antibiotics could be steadily released from SRDDS and about 63% of the drug had been released by the day 28. In vivo , a unit of SRDDS could steadily release drug in effective concentration for at least 6 weeks. CONCLUSION: When the SRDDS was used underneath the barrier membranes, it seems to be able to prevent or at least reduce the bacterial colonization on the barrier membranes. [
出处
《牙体牙髓牙周病学杂志》
CAS
2000年第5期276-279,共4页
Chinese Journal of Conservative Dentistry
关键词
给药系统
羟基磷灰石
强力霉素
引导组织再生
drug delivery system
hydroxyapatite
doxycycline
guided tissue regeneration
