摘要
目的 探讨糖尿病视网膜病变 (DR)患者的上皮细胞生长因子 (EGF)、肿瘤坏死因子 (TNF)、血清超氧化物歧化酶 (SOD)和血液流变学的变化。方法 测定 30例糖尿病视网膜病变 (DR)患者 ,2 9例糖尿病无视网膜病变者 (NDR)和 2 9例对照者 (C)的 EGF、TNF、SOD水平和血液流变学指标。结果 糖尿病患者的 EGF、TNF和血液粘度明显高于对照组 ;而 SOD均值明显低于对照组。增殖型 DR患者的 EGF、TNF和血液粘度明显高于单纯型 DR患者 ,而 SOD均值明显低于单纯型 DR患者。结论 DR的发生、发展与 EGF、TNF和血液粘度升高有关 ,与血清
Objective To investigate the change of epithelium growth factor(EGF), tumor necrosis factor (TNF), superoxide dismutese(SOD) and hemorrheology (HL) in patients with diabetic retinopathy.Methods EGF、TNF、SOD levels and HL changes have been measured in 30 NIDDM patients with retinopathy (DR group), 29 NIDDM patients without retinopathy (NDR group), and 29 patients with senile cataract and without diabetes as control (C group). Results The mean levels of EGF、TNF and blood viscosity were significantly higher in both DR and NDR group than those in C group; the mean levels of SOD was significantly lower in both DR and NDR group than that in C group. The EGF、TNF and blood viscosity was significantly higher in proliferative type DR than in background DR; The SOD was significantly lower in proliferative type DR than in background DR.Conclusion The development of diabetic retinopathy is related to the increase of EGF、TNF、blood viscosity and decrease of serum SOD.
出处
《眼科新进展》
CAS
2000年第5期350-352,共3页
Recent Advances in Ophthalmology
关键词
糖尿病
视网膜病变
EGF
TNF
SOD
血液流变学
diabetic retinopathy
epithelium growth factor
tumor necrosis factor
superoxide dismutase
hemorrheology
