摘要
目的：分析子宫内膜息肉（EP）组织中17β-羟类固醇脱氢酶2（1713HSD2）的表达及意义。方法：收集郑州大学第一附属医院生殖医学中心及妇科就诊的育龄期妇女息肉组织（40例，A组）以及正常内膜组织（40例，B组），免疫组化法测定17βHSD2的表达；同时收集研究对象年龄、体质量指数信息以及月经第2—4天血清，采用电化学发光免疫分析法测定5项性激素水平。结果：（1）两组患者的年龄、体质量指数以及血清5项性激素水平无显著差异（P〉0．05）。（2）1713HSD2在各期EP组织中的表达均明显下降（P〈0．05）。结论：子宫内膜局部17βHSD2表达减少可能是EP发生的重要因素。
Objective To explore the expression of 17 beta hydroxysteroid dehydrogenase 2 （17 β HSD2） in endometrial polyps （EP） and its significance. Methods The normal endometrial tissues （control group） and polyp tissues （study group） were collected from 40 control subjects and 40 patients who received hysteroscopy inspection or diagnostic curettage at the reproductive medicine center and the department of gynecology of the first affiliated hospital of Zhengzhou university. Expressions of 17β HSD2 in different tissues were measured by immunohistochemistry. Age and body mass index were collected. Serum sex hormone were deteeted in the menstrual period of 2 to 4 days. Results There were no significant differences in age, body mass index, and serum sex hormone levels between the two groups （P 〉 0.05）. Expressions of 17β HSD2 were significantly reduced in EP tissue of different stages （P 〈 0.05）. Conclusion The decreased expression of 17β HSD2 can be an important factor of endometrial polyps.
出处
《实用医学杂志》
CAS
北大核心
2013年第17期2809-2811,共3页
The Journal of Practical Medicine
基金
广东省科技计划项目(编号:20120318080)
