摘要
为观察硫普罗宁 (Tiopronin ,MPG)对放疗所致小鼠白细胞减少的预防和治疗作用。方法 采用60 Co -γ射线造成外周血白细胞减少的动物模型进行试验 ,观察MPG防治由放疗所致白细胞减少的作用。结果 预先用MPG不同剂量对小鼠经口灌胃 (ig)或腹腔注射 (ip)用药 5天 ,给动物一次60 Co -γ射线全身照射 480Rad/ 3min ,及先给动物进行一次60 Co -γ射线全身照射 480Rad/ 3min后 ,用MPG不同剂量对小鼠ig或ip进行治疗。然后均于放疗后第 3天、第 5天计数白细胞总数 ,与单用放疗组相比具有显著性差异。结论 MPG具有明显的预防和治疗由60 Co -γ射线所致的小鼠白细胞减少的作用。
Objective To observe the effects of tiopronin(MPG) on the prevention and treatment of leukocytopenia induced by radiotherapy in mice.Methods 60 Co-γ ray was adopted to make the model of peripheral blood cell reducing in mice,and MPG prevented and treated the leukopenia caused by radiotherapy was observed.Results After mice were administered 250 mg·kg -1 and 500 mg·kg -1 of MPG once daily for 5 days by intragastic(ig),or 150 mg·kg -1 and 300 mg·kg -1 of MPG once daily for 5 days by intraperitoneal(ip),and 60 Co-γ irradation at 480 Rad/3 min once,then counted the total white blood cell count(WBC) at the 3th day and 5th day.Compared with the model control group,the defference was very notable( P <0.01).If 60 Co-γ irradation at 480 Rad/3 min at first ,and the different doses of MPG was given by ig or ip,then counted WBC at the 3th day and 5th day.Compared with the model control group,the difference between the experiment and the model control groups were significant( P <0.05, P <0.01).Conclusion The results suggested that the MPG had obvious action of prevention and treatment on leukopenia induced by radiotherapy in mice.
出处
《河南肿瘤学杂志》
2000年第4期238-239,共2页
Henan Journal of Oncology
基金
国家"八五"攻关资助!课题
课题号 :(85 -92 2 -0 2 -2 7)
