摘要
目的:探讨中药全浸膏制剂与各种辅料合用的防潮效果。方法:通过将黄芪提取物形成的全浸膏与乳糖、可溶性淀粉、*微晶纤维素、磷酸钙、磷酸氢钙、磷酸二氢钙等,按原料+原料7%的辅料比例混合,在恒定湿度下放置36小时,分别观察放置过程中几个时间点各种辅料的吸湿率,吸湿率低即为防潮效果较佳。结果:乳糖作为辅料其吸湿性最低,防潮效果最好,其次是可溶性淀粉,磷酸钙等无机盐和微晶纤维素的吸湿性差不多。结论:乳糖和可溶性淀粉虽然防潮效果较佳,但它们吸湿后对药物的外观形态改变较大,吸收的水分易扩散到有效药物成分中去,固其综合防潮效果受到一定影响。与微晶纤维素和无机盐相比各有优缺点,实际应用中可灵活应用。
Objective：To explore the moistureproof effects of the combination of total extract of ttrational Chinese medicine and various excipients.Methods：Total extract formulated by astragalus mongholicus extract is respectively mixed together with lactose,soluble starch,microcrystalline cellulose,calcium phosphate,calcium hydrophosphate,monocalcium phosphate and the like according to the proportion of ＂raw material ＋ excipient（7% of the amount of raw material）＂and then laid under constant humidity for 36 hours;respectively observe the moisture rates of each excipient at every time point during the placement and the low moisture rate can be regard to be good moistureproof effect.Results：As excipient,lactose has the lowest hygroscopicity and the best moistureproof effect with soluble starch in second place;inorganic salt like calcium hydrophosphate and microcrystalline cellulose have about the same hygroscopicity.Conclusion：Although lactose and soluble starch have relatively good moistureproof effect,they can cause big changes to the appearance of drugs after moisture absorption and the absorbed water can easily diffuse into the effective drug components,therefore,influencing the general moistureproof effects in some way.Comparing with microcrystalline cellulose and inorganic salt,each has its own advantages and disadvantages,being worth flexibly using in the practical application.
出处
《中国医药导刊》
2013年第5期917-918,共2页
Chinese Journal of Medicinal Guide
关键词
辅料
中药全浸膏制剂
防潮
Exicipient
TCM
Whole TCM extract preparation
Moisture-proof
