摘要
【目的】探讨大剂量盐酸氨溴索治疗呼吸机相关性肺炎（VAP）的临床疗效。【方法】本院60例VAP患者随机分为治疗组和对照组，每组30例。对照组患者采用常规超声雾化治疗；治疗组在超声雾化治疗的同时静脉滴注大剂量盐酸氨溴索。分别记录比较两组患者ICU住院天数、机械通气治疗天数及治疗前后临床肺部感染评分变化。【结果】治疗组的IcU住院天数明显低于对照组，且差异具有显著性（P〈0．05），机械通气治疗天数与对照组相比较差异无显著性（P〉0．05），治疗后临床肺部感染评分明显低于对照组，且差异具有显著性（P〈0．05）。【结论】大剂量盐酸氨溴索治疗VAP有良好的临床疗效。
[Objective] To explore the clinical efficacy of high dose of ambroxol hydrochloride for the treat- ment of ventilator associated pneumonia（VAP）. [Methods] A total of 60 VAP patients in our hospital were randomly divided into treatment group and control group with 30 cases in each. Control group was given rou- tine ultrasonic atomization therapy, while the treatment group was given ultrasonic atomization and intravenous injection with high dose of ambroxol hydrochloride. The day of ICU stay, days of mechanical ventilation and the change of clinical pulmonary infection score before and after treatment were recorded and compared be- tween two groups. [Results] The day of ICU stay in treatment group was obviously less than that in control group, and there was significant difference（ P 〈0.05）. There was no significant different in the days of me- chanical ventilation between two groups（ P 〉0.05）. After treatment, the score of clinical pulmonary infection in treatment group was obviously lower than that in control group, and there was significant difference（ P 〈0.05）. [Conclusion] High dose of ambroxol hydrochloride for the treatment of VAP has good efficacy.
出处
《医学临床研究》
CAS
2013年第7期1380-1382,共3页
Journal of Clinical Research
