摘要
目的:探讨降钙素原(PCT)、C反应蛋白(CRP)在不同阶段新生儿感染中的诊断价值。方法:采用回顾性分析方法对本院入院时同时行PCT、CRP检测的119例新生儿根据感染程度分为三组即全身感染组、局部感染组及无感染组,再根据日龄3 d为界分为两大组,对比分析PCT、CRP检测结果。结果:在0～3 d的新生儿组,PCT、CRP在全身感染组、局部感染组检测结果分别与非感染组比较,差异无统计学意义(P>0.05),在生后4～28 d的新生儿组,PCT、CRP在全身感染组检测结果较局部感染组和无感染组明显增高,差异有统计学意义(P<0.01)其中PCT的敏感性和特异性均高于CRP;所有感染患儿和无感染患儿比较,PCT和CRP的检测特异性较高,但敏感性较低。结论:对生后4～28 d新生儿,PCT和CRP均可作为全身感染的早期诊断指标,尤其是PCT的检测。不推荐PCT和CRP检测作为生后0～3 d新生儿的感染诊断指标。
Objective： To study the diagnostic value of procalcitonin and C-reactive protein to early neonatal infection in different stages.Methods： The research was made in a retrospective way in which we,based on the seriousness of infection,divided the 119 neonates of 4 ～ 28 days old whose PCT and CRP were examined when entering our Hospital into three groups,namely,general infection,local infection,and non-infection as control.The data were compared with those of 0 ～ 3 day neonates examined with PCT,CRP and WBC.Results： Among the neonates of 0 ～ 3 days old,there is no remarkable difference（P 0.05） in PCT and CRP in the general infection and local infection groups compared with the non-infection group respectively;among the neonates of 4 ～ 28 days old,PCT and CRP in the general infection group are obviously higher than in the groups of local infection and non-infection（P 0.01）,PCT being more sensitive and distinctive than CRP;comparing the infection groups（general and local infection） with the control group,though PCT and CRP are highly distinctive,they are less sensitive.Conclusions： For neonates of 4 ～ 28 days old,PCT and CRP,especially PCT,can both be used as the diagnostic index in early intensive infection,but they are not recommended as the diagnostic index for 0 ～ 3 day neonates.
出处
《航空航天医学杂志》
2013年第7期772-774,共3页
Journal of Aerospace medicine
关键词
降钙素原
C反应蛋白
新生儿感染
procalcitonin
C-reactive protein
neonatal infection
