摘要
目的:探讨分析促肾上腺皮质激素(ACTH)与继发性糖尿病的相关性。方法:64例2型糖尿病(T2DM)患者分为腹型肥胖组与非腹型肥胖组,每组32例,同时选取50例同期于我院进行体检的健康者作为对照组,测定各组血清ACTH的水平,并分析其与其他相关指标的相关性。结果:所有继发性糖尿病患者的ACTH水平均高于对照组(P<0.05),T2DM腹型肥胖组ACTH水平明显高于T2DM非腹型肥胖组(t=3.052,P<0.05);Pearson′s相关性分析结果显示T2DM非腹型肥胖组患者的ACTH水平与血糖(FPG)、糖化血红蛋白(GHbA1c)、血清胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)及皮质醇的水平呈正相关(r=0.788、0.579、0.533、0.749、0.822,P<0.05);T2DM腹型肥胖组患者的ACTH水平与体重指数(BMI)、FPG、GHbA1c、FINS、HOMA-IR及皮质醇的水平呈正相关(r=0.430、0.509、0.558、0.721、0.602、0.610,P<0.05)。结论:高ACTH与高皮质醇与继发性糖尿病患者高血糖及胰岛素抵抗密切相关,且合并腹型肥胖的患者病情更为严重,在对这类患者进行治疗时,应考虑将患者ACTH与皮质醇水平控制在合理的范围内。
Objective ： To study the relationship between adrenocortical hormone（ACTH） and type 2diabetes mellitus（T2DM）.Methods ： A total of 64patients with T2DM were divided into the abdominal obesity group and none-abdominal obesity group by half.Fifty healthy people were selected as the control. Level of serum ACTH of all the cases were measured and the relationship between indexes was analyzed.Results ： Level of ACTH of all the patients with T2DM was higher than that of the control group（t=2.844,6.209;P0.05）;level of ACTH of abdominal obesity group were higher than that of the none-abdominal obesity group（t=3.052,P0.05）.Pearson′s correlation analysis showed that level of ACTH of non-abdominal obesity T2DM patients was positively correlated with fasting plasma glucose（FPG）,GHbA1c,fasting insulin（FINS）,insulin resistance index（HOMA-IR） and level of cortisol（r=0.788,0.579,0.533,0.749,0.822;P0.05）;level of ACTH of abdominal obesity T2DM patients was positively correlated with body mass index,FPG,GHbA1c,FINS,HOMA-IR and level of cortisol（r=0.430,0.509,0.558,0.721,0.602,0.610;P0.05）.Conclusion ： High level of ACTH and cortisol are closely related with high level of FPG and insulin resistance.And the situation of patients with abdominal obesity is more severe.Level of ACTH and cortisol should be controlled in a rational range.
出处
《海南医学院学报》
CAS
2013年第10期1415-1418,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210817)~~
