摘要
[目的]研究黄秋葵多糖抗小鼠运动性疲劳的作用及其机理。[方法]清洁级ICR小鼠随机分为四组:黄秋葵多糖低、高剂量组(分别用黄秋葵多糖150、300mg/(kg.d))、阳性对照组(生晒参水提物200mg/(kg.d))和空白对照组(等量蒸馏水),连续灌胃21d后,测定小鼠的游泳时间、体重变化、血乳酸、血尿素氮、肝糖元指标。[结果]低、高2个剂量黄秋葵多糖均可显著延长小鼠的游泳时间(P<0.05),降低小鼠血乳酸、血尿素氮水平(P<0.05),并增加肝糖原含量(P<0.05);其作用均与阳性对照生晒参水提物相当(P>0.05)。[结论]黄秋葵多糖具有明显的抗小鼠运动性疲劳作用,其作用机理可能通过提高肝糖原含量增加能源物质储备、增加葡萄糖的有氧分解、减少葡萄糖的无氧酵解、减少蛋白质的分解、提高产能效率而发挥作用。
[Objective]To investigate the anti-fatigue effect of the polysaccharide from Okra in mice.[Methods] 40 male mice were randomly divided into 4 groups including low-,high-dose groups（treated with the polysaccharide from Okra at dose of 150,300 mg/kg.d）,positive control group（treated with water extract of Dried Fresh Ginseng,at dose of 200 mg/kg.d） and control group（treated with distilled water）.All the 4 groups were treated by gavage for continuous 21 days and tested for their weight-loaded swimming times as well as blood urea nitrogen,blood lactic acid and hepatic glycogen levels.[Results]The groups treated with the polysaccharide from Okra significantly prolonged the exhaustive swimming time of mice,decreased the contents of both blood urea nitrogen and blood lactic acid and increased the content of hepatic glycogen,and their effects were as effective as Dried Fresh Ginseng.[Conclusion]The polysaccharide from Okra could resist fatigue in mice in a dose-dependent manner.
出处
《浙江中医药大学学报》
CAS
2013年第7期902-904,共3页
Journal of Zhejiang Chinese Medical University
基金
浙江省科技厅2010年重大科技专项(2010C12013)~~
关键词
黄秋葵
多糖
抗疲劳
运动性疲劳
运动耐力
肝糖原
生晒参
Okra
polysaccharide
anti-fatigue
spprt fatigue
exercise capacity
hepatic glycogen
suncured ginseng
