摘要
目的:探讨强化他汀治疗对非酒精性脂肪性肝(NAFLD)的降脂疗效、安全性和改善动脉弹性等的影响。方法:收集2009年5月-2012年10月体检中心符合NAFLD的400例患者,根据患者的意愿分为A组(药物组)、B组(生活干预组)、C组(药物+生活干预组)、D组(安慰剂组),各100例。降脂药物采用阿托伐他汀40mg/d;生活干预:每天快速行走1h;饮食要清淡少肉,禁吃动物内脏,多吃水果;试验时间为6个月。结果:C组的效果明显优于其他三组,差异有统计学意义(P<0.05)。结论:他汀药物通过对患者进行降脂,抑制了血管内皮氧化应激反应,能够改善肝功能和动脉弹性,减少NAFLD患者心血管发生率。
Objective： To discuss the intensive statin therapy for non-alcoholic fatty liver（NAFLD） in patients with lipid-lowering efficacy, safety and improve arterial elasticity.Methods： Collected from May 2009 to October 2012 physical examination center in line with the 400 patients of NAFLD, according to the patient＇ s wishes, can be divided into group A（drug）, group B （life intervention）, group C（drug and life interventiondrug）, group D（placebo）, and 100 cases for each.Lipid-lowering drug use atorvastatin 40 mg/d; 1 h life intervention： fast walking every day; Diet to light meat less, from the internal organs of animals, to eat more fruit; Test time was 6 months.Results： The effect of group C was obviously better than the other three groups（P〈0.05）. Conclusion： Statins in patients with lipid-lowering, inhibits vascular endothelial oxidative stress reaction, can improve liver function and arterial elasticity, reduce the incidence of cardiovascular patients with NAFLD.
出处
《中外医学研究》
2013年第22期157-158,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
非酒精性脂肪肝
降脂疗法
动脉弹性
Non-alcoholic fatty liver disease
Lipid-lowering therapy
Arterial elasticity
