摘要
目的:观察活血化瘀法改善原发性支气管肺癌高凝状态的疗效。方法:将60例符合肺癌高凝状态诊断标准的患者随机分为研究组30例,对照组30例。对照组仅给予常规抗肿瘤治疗,如EP方案、NP方案等;研究组在常规抗肿瘤治疗的基础上加用注射用血栓通,16 d为1个疗程,间歇5 d进行下一个疗程,6个疗程后比较两组患者凝血指标及D二聚体,生活质量评估(Karnofsky评分)及中医临床症状积分评定。结果:临床研究表明,研究组经治疗后患者凝血指标TP、APTT时间显著延长(P<0.01),FIB、D二聚体显著下降(P<0.01),与对照组比较,FIB、D二聚体降低显著(P<0.01);研究组中医临床症状改善明显优于对照组(P<0.01);生活质量有所提高。结论:活血化瘀法能改善肺癌患者高凝状态,改善血瘀症状,有可能提高患者生活质量。
Objective ： To observe the effect of the treatment of activating blood circulation to dissipate blood stasis in improving hypercoagulable state of primary bronchogenic carcinoma （ PBC ） .Methods ： 60 cases met the standards of patients with lung cancer hypercoagulable state were randomly divided into 30 cases of the study group, 30 cases of the control group.The control group only received conventional antineoplastic therapy, while the study group were treated with Xueshuantong injection besides the therapy mentioned above, 16 days as a treatment cycle, and every 5 days there came another treatment cycle.After 6 cycles, the general situations of two groups were compared, including coagulation index, D-dimers, appraisal of life quality （ Karnofsky score ） and Chinese medicine clinical symptoms scores assess. Results： Clinical studies have shown that the study group can significantly prolong TP and APTT （ P〈0.01 ）, dramatically reduce the index of FIB and D-dimers （ P〈0.01 ）; the improving efficacy of TCM symptoms of study group was better than that of control group （ P〈0.01 ）; and the qualities were improved accordingly. Conclusion ： The treatment of activating blood circulation to dissipate blood could improve the hypercoagulable state of primary bronchogenic carcinoma （ PBC ） and the symptoms of blood stasis and probably improve the life quality.
出处
《辽宁中医药大学学报》
CAS
2013年第8期182-185,共4页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
活血化瘀法
肺癌高凝状态
血栓通
treatment of activating blood circulation to dissipate blood
hypereoagulable state of PBC
Xueshuantong injection
