摘要
背景与目的晚期肺癌患者的治疗以提高疗效和改善生活质量为最终目的,肺功能指标是较好的评价指标。本研究探讨晚期肺癌患者肺功能改变及肺功能指标与患者生存期的相关性。方法通过对59例晚期肺癌患者的肺功能进行检测,且与患者生存期进行相关性分析,并与63例健康人进行对照。结果晚期肺癌患者的肺通气及弥散功能指标明显低于正常,与对照相比有统计学差异。肺功能指标中肺活量(vital capacity,VC)、第1秒用力呼出量(forced expiratory volume in one second,FEV1)、用力肺活量(gorced vital capacity,FVC)、最大呼气流速(peak expiratory flow,PEF)、最大呼气流速%(peak expiratory flow%,PEF%)、最大通气量(maximal ventilatory volume,MVV)与患者生存期呈正相关(r分别为0.29、0.28、0.28、0.27、0.26、0.28,P<0.05),残气量/肺总量(residualvolume/total lung,RV/TLC)值与患者生存期呈负相关(r=-0.31,P<0.05)。结论肺癌患者存在肺功能的减退,肺癌患者肺功能指标中VC、FEV1、FVC、PEF、PEF%、MVV、RV/TCL值与患者生存期具有相关性,肺功能的部分指标可作为肺癌患者预后评估的重要因素之一。
Background and objective To those patients with advanced lung cancer, the ultimate objective is to improve the curative effect and quality of life, lung function indexes are an important factor. We investigate the change of lung function and the relationship between pulmonary function indexs and survival time in patients with advanced lung cancer. Methods Lung function was detected in 59 cases with lung cancer and 63 normal controls. The relationship between pulmo- nary function indexs and survival time was analyzed. Results There was significant difference in ventilation function and diffusing capacity between in lung cancer group and control group. Vital capacity （VC）, forced expiratory volume in one second （FEVI）, forced vital capacity （FVC）, peak expiratory flow （PEF）, peak expiratory flow% （PEF%）, maximal ventilatory volume （MVV） were positively correlated with survival time in patients with advanced lung cancer （r=0.29, 0.28, 0.28, 0.27, 0.26, 0.28, P〈0.0S）, residual volume/total lung capacity was negatively correlated with survival time （r=-0.31, P〈0.0S）. Conclusion The lung function decreases in the patients with lung cancer. VC, FEVI, FVC, PEF, PEF%, MVV, residual volume/total lung capacity were correlated with survival time in patients with advanced lung cancer. The pulmonary function indexs were important marker of prognosis in patients with lung cancer.
出处
《中国肺癌杂志》
CAS
北大核心
2013年第7期359-363,共5页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
肺功能
生存期
Lung neoplasms
Lung function
Survival time
