摘要
目的:研究脑泰胶囊对大鼠脑缺血再灌注损伤的保护作用。方法:70只SD大鼠随机分为假手术组、模型组、尼莫地平组、血栓通组、脑泰胶囊低、中、高剂量组。通过线栓大脑中动脉制备脑缺血再灌注大鼠模型,苏醒后对其神经功能行为学进行评分;缺血2 h再灌注7 d后,用T T C染色法检测脑组织梗死体积并进行病理切片观察神经细胞的形态结构的改变。结果:脑缺血再灌注后,脑泰胶囊组神经功能缺失症状减轻(P<0.05或P<0.01);与模型组比较,脑泰胶囊组的脑组织梗死体积显著减少(P<0.01)。结论:脑泰胶囊对缺血再灌注脑损伤有保护作用。
Objective：The protective effect of Naotai Capsule was observed on the rats with cerebral ischemia reperfusion.Methods： 70 Sprague-Dawley（SD） rats were randomly divided into 7 groups：sham operation group,model group,Ninodiping group,Xueshuantong group,Naotai Capsule groups（low,middle and high dosages）.Animals were subjected to cerebral ischemia reperfusion through middle cerebral artery occlusion（MACO） with silk thread ligation for 2 h and sacrificed 7 days after reperfusion.Some indexes were detected such as neurological deficit scores,and triphenyltetrazolium chloride（TTC） dyeing was used for observing the pathological changes.Results： The highest neurological score was in the model group,descending significantly in Naotai Capsule groups,Ninodiping group and Xueshuantong group,especially in the Naotai Capsule middle and high dosage groups（P0.01）.Compared with the model group,there was a decrease in infarct region of cerebral ischemia reperfusion rats in medicine treatment groups（P0.01）.Conclusion： Naotai Capsule has a neuroprotective effect against cerebral ischemic reperfusion injury.
出处
《中华中医药学刊》
CAS
2013年第7期1586-1587,I0007,共3页
Chinese Archives of Traditional Chinese Medicine
基金
湖南省自然科学基金重点课题资助项目(09JJ3073)
教育部博士点基金资助项目(20094323110002)
湖南高校创新平台开放基金资助项目(09k060)
关键词
脑缺血再灌注
神经保护
TTC染色
脑泰胶囊
cerebral ischemic reperfusion
neuroprotective effect
TTC dying
Naotai Capsule
