摘要
目的:研究肝切除术围手术期乌司他丁对肝功能及机体的保护作用。方法:将158例拟行肝切除术的患者随机分为乌司他丁组和对照组,分别于手术当日和术后第1、3、5、7天抽取全组患者外周静脉血,测定ALT、AST、TBIL、TNF-α及IL-6。结果:术后上述观测指标较术前均有不同程度升高,乌司他丁组上升幅度均较对照组低(P<0.05),且乌司他丁组的部分指标恢复至术前水平的时间较对照组短(P<0.05)。结论:对肝切除术患者,乌司他丁具有一定保护肝功能及减轻炎症反应、保护机体等作用。
Objective To study the protective effects of ulinastatin applied in the perioperative period of hepatectomy on liver function and body.Methods 158 patients who received hepatectomy were randomly divided into ulinastatin group and control group.ALT,AST,TBIL,TNF-α and IL-6 levels were measured in the day of surgery and 1,3,5,7 days after surgery in both groups.Results The ALT,AST,TBIL,TNF-α and IL-6 levels were increased after surgery in both groups;and the increases in ulinastatin group were lower than those in control group（P〈0.05）;and the time of returning to preoperative levels of some indicators in ulinastatin group was shorter than those in control group（P〈0.05）.Conclusion Ulinastatin can protect liver function and reduce inflammation in patients receiving hepatectomy.
出处
《实用医学杂志》
CAS
北大核心
2013年第14期2243-2245,共3页
The Journal of Practical Medicine
